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1242

Scientific literature review: Clinical microbiology and virology

Detection of viruses in clinical samples by use of metagenomic sequencing and targeted sequence captureWylie KM, Wylie TN, Buller R, Herter B, Cannella MT, Storch GA. J Clin Microbiol 2018; 56(12): pii: e01123-1Metagenomic shotgun sequencing (MSS) is a revolutionary approach to viral diagnostic testing that allows simultaneous detection of a broad range of viruses, detailed […]

1245

Placental growth factor testing reduces time to diagnosis for women with suspected pre-eclampsia

Pre-eclampsia is a condition that affects approximately 2–8% pregnancies worldwide and, although the cause is not really understood, is thought to be due to poor function of the placenta. Early signs that create suspicion of pre-eclampsia in the mother typically include hypertension, proteinuria and edema (particularly of the pitting type) of the ankles. Symptoms of […]

1247

Drug testing, fingerprints and the future

Standard drug testing is regularly carried out using urine, blood or oral fluid. However, fingerprints present a good alternative, as the sample collection is non-invasive, rapid and safe. Herein, we describe the application of two different testing methods for the detection of cocaine in fingerprint samples. by Dr Catia Costa, Dr Mahado Ismail and Dr […]

1248

Biomarkers for improving the diagnosis of acute interstitial nephritis

Acute interstitial nephritis (AIN) may be the cause of more than 15 % of instances of acute loss of kidney function. Diagnosed early, it can often be successfully treated; however, lack of obvious symptoms means it can be easily missed. Left untreated, AIN can progress to chronic kidney disease. Currently, clinical diagnosis is confirmed by […]

1250

MicroRNAs show potential as molecular biomarkers for graft-versus-host disease

Graft-versus-host disease is a serious complication following hematopoietic stem cell transplantation (HSCT), with a high mortality rate. A clearer understanding of the molecular pathogenesis may allow robust biomarker identification and improved therapeutic options. MicroRNAs (miRNAs) are short non-coding regulatory RNAs that are expressed in both tissue and body fluids, and show great potential as clinically […]