By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]
Endometriosis is an incurable, chronic condition, associated with debilitating pain and reduced fertility. It is thought to affect 190 million women worldwide and is associated with huge costs to the economy though loss of earnings and cost of health-care/treatment. Currently, diagnosis on average takes around 8 years. CLI chatted to Dr Barbara Guinn (Centre for […]
Getting the most from every drop – new advances in blood separation Alexandra Sommer, Senior Product Manager, Clinical Diagnostics at Tecan
By Kellie Madigan The quality and consistency of immunostaining contributes highly to productivity for pathologists and cellular pathology laboratory managers. An evaluation study among key opinion-leaders in this area of healthcare has sought to understand how today’s pathologists perceive staining quality, its impact on their working life, and what the term ‘quality’ covers. This article […]
Running clinical lab tests is a labour-intensive business. Even if the actual test is done by an automated platform, many stages still require manual handling of the specimens, which can limit throughput and allow the potential for errors to occur (we’re only human, after all!). Increasing the amount of automation circumvent these limitations and CLI […]
By Serena Shell, Bheemraj Ramoo, C. Clinton Frazee III and Prof. Uttam Garg Mycophenolic acid is an immunosuppressant administered to patients undergoing various organ transplants. Therapeutic drug monitoring of mycophenolic acid is important to reduce drug toxicity and organ rejection. This is accomplished using several techniques including immunoassays, high-performance liquid chromatography with an ultraviolet detector […]
By Dr Laura M. Labay and Dr Sherri L. Kacinko The forever contaminants of our generation PFAS (perfluoroalkyl and polyfluoroalkyl substances) are synthetic chemicals that have a wide range of industrial and manufacturing applications because of their chemical and thermal stability and their hydrophobic and lipophobic characteristics. PFAS are persistent in the environment, bioaccumulate in […]
By Dr Jacqueline Gosink Autoimmune neurology is a rapidly growing field driven by the ongoing discovery of novel neural autoantibodies associated with recognizable clinical syndromes. These diseases can affect the central, peripheral and autonomic nervous systems and may co-occur with cancer. Today’s testing landscape encompasses more than 60 neural autoantibodies targeting different intracellular proteins, receptors […]
By Dr F. van Delft, Dr M. Schuurbiers, Dr van den Heuvel and Dr H. van Rossum The development of immunotherapy and other targeted therapies has given rise to significant improvements in the treatment of non-small cell lung cancer. However, some patients do not benefit from these therapies and it is, therefore, important for a […]
We all know that detecting cancer early is the key to obtaining the best treatment outcomes. However, how do you do this when some sectors of the population struggle to access healthcare and does point-of care testing make it possible to take health screening to the people who need it? CLI caught up with Professor […]
November 2025
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