by Dr Yoonyoung Lee Tumour heterogeneity and spatial organization within the tumour micro-environment are important factors influencing cancer progression and therapeutic response. Spatially resolved cell sorting technologies enable selective isolation of spatially defined cellular populations directly from tissue sections while preserving tissue context for downstream molecular analysis, thus supporting advances in tumour characterization and precision […]

Volatile organic compounds (VOCs) are released from our bodies in our breath, sweat, blood and urine as a result of metabolic activity and so provide a window on our metabolic and physiological status. These VOCs change in response to disease, providing the potential for disease-specific VOCs in the breath to be used as non-invasive biomarkers […]

Iron deficiency and iron deficiency anemia are remarkably common worldwide. However, recommended ferritin cut-off concentrations can vary widely and there is room for improvement in standardization across different assay platforms. Dr Katie Troike and Dr Adam McShane (Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA) recently conducted their own re-evaluation of ferritin […]

The congenital neutropenia syndromes are rare conditions caused by mutations in genes associated with various cell processes. While their clinical presentations may overlap, their natural histories vary. Accurate diagnosis of the genetic etiology of specific conditions is crucial for providing individually tailored management, as the different syndromes have different risk profiles for progression to bone […]

Using ferritin as a biomarker for hemophagocytic lymphohistiocytosis can reduce delays in treatment due to negative or pending hemophagocytosis results