Mindray launches novel platelet counting technology for clinical laboratories
International medical technology company Mindray has introduced new platelet counting technology to European markets, incorporating artificial intelligence and multiple detection methods to enhance accuracy in clinical haematology laboratories. The CAL 8000 Cellular Analysis Line aims to reduce pseudothrombocytopenia and pseudothrombocytosis errors in diagnostic testing.
The system combines several analytical approaches, including a high-precision optical detection method (PLT-H) that utilises sophisticated algorithms to minimise interference. The technology incorporates automated self-de-aggregation capabilities, employing heating, stirring, and de-aggregation processes to address ethylenediaminetetraacetic acid-induced platelet clumping.
Enhanced detection for low platelet counts
For samples flagged as abnormal, the system’s PLT-O fluorescent staining method provides additional verification. This technology automatically increases particle counting sensitivity by a factor of eight without requiring additional sampling, particularly beneficial for accurate low platelet count determination.
Morphological analysis capabilities
The integrated digital morphology analyser employs PLT-M technology for automated platelet count estimation through advanced imaging methods. Additionally, the PLT-Pro scanning system can identify platelet aggregation by examining platelets in the body, edge, and tail of blood smears, completing analysis within one minute – a significant improvement over traditional methodologies.
False platelet counts can have serious clinical consequences. Misdiagnoses may result in unnecessary anxiety, additional testing, inappropriate medication administration, or surgical delays. Conversely, pseudothrombocytosis can mask potentially dangerous low platelet conditions or lead to incorrect diagnoses when normal counts are reported as elevated.
Laboratory efficiency
The system’s automation capabilities can reduce processing time for aggregated samples from two hours to approximately 30 minutes. According to Huan Qi, Director of Clinical Research, Medical Affairs at Mindray, the technology combination enables “99.9% of samples to be reported with accurate platelet count results, without the need for manual intervention.”
Clinical validation
Professor Marie Christine Béné from the Faculty of Medicine at Nantes University noted that the technology’s disaggregation protocol and optical staining methods could improve laboratory productivity by reducing the time required for manual examination of low platelet counts and platelet clumping.
The technology’s effectiveness has been evaluated and presented at the International Society for Laboratory Haematology’s 2024 International Symposium on Technical Innovations in Laboratory Haematology by specialists from France and Poland.
For more information, visit: www.mindray.com
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