Monoclonal antibodies to Clostridia GDH

Clostridium difficile-associated diarrhoea (CDAD) is the leading cause of nosocomial diarrhoea. The spread of this bacterium is difficult to control due to its resistant spores that survive on many surfaces, so rapid detection is crucial to its control. Most rapid tests target the toxins (A & B) produced during the infection. Another diagnostic target is glutamate dehydrogenase (GDH), an enzyme produced and released during bacterial growth. Studies have shown that GDH detection together with toxin detection by EIA or PCR significantly improves assay specificity. Three new monoclonal antibodies to Clostridia GDH validated by ELISA are now available. These antibodies represent a new set of tools for rapid detection development.

Supplier: Virostat

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