C248 Genalyte

One-step screening for common connective tissue disease autoantibodies

Created to simultaneously screen for several of the most common autoantibodies found in autoimmune connective tissue disorders, such as systemic lupus erythematosus (SLE), the Maverick ENA 4 and ENA 6 assay kits are the first available for the Maverick Detection System. Their simplified one-step workflow delivers accurate results in 15 minutes and can be run using very small volume samples from a variety of matrices, including serum and plasma. The ENA 4 assay tests for the presence of four of the most commonly measured extractable nuclear antigens (ENA), including SS-A, SS-B, Sm and RNP, while the ENA 6 assay includes two additional commonly measured antigens–Scl-70 and Jo-1, so covering six multiplexed tests per sample. The assay results are highly reproducible, show excellent correlation to ELISA and are up to ten times more sensitive. The assays are available to participants in the company’s Early Access programme, which enables scientists to gain pre-launch access to multiplexed autoantibody assays and the Maverick Detection System. This uses a proprietary chip based on silicon photonics to simultaneously analyse multiple proteins from a single small sample. The multiplexing technology simultaneously screens for the detection of autoantibodies using a one-step process that eliminates the washes, incubations, reagents and processing steps typically associated with other technologies. Semi-quantitative results are reported for each analyte, eliminating the need for reflex testing. The assays are simple to use and rapid – results are available in only 15 minutes, including just two minutes of hands-on time. A number of higher plexed assays for autoimmune diseases, including rheumatoid arthritis, celiac disease and others, are also in development.

Supplier: Genalyte Inc.

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