Extending the company’s range of diagnostic testing solutions, the kits enable DNA extraction and the identification of polymorphisms in genes linked to disease or drug metabolism. The kits are real time PCR-based, and validated on multiple PCR instruments from leading manufacturers. These include thrombosis kits for the detection of polymorphisms in F5 and F2 genes, supporting disease management. The drug sensitivity kits determine an individual’s susceptibility to indirect anticoagulants and other drugs, including polymorphisms in CYP2C9, VKORC1, CYP2C19 genes. This knowledge is important in correct dosage prescription, which can vary hugely across genotypes. The Multi DNA extraction kit provides fast, easy extraction from various sample types, including serum, plasma, dry blood spots, urine, saliva and epithelial cells.
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The hormone 1,25 dihydroxy vitamin D is formed in the kidney and has important functions in calcium metabolism; hence impaired kidney function can result in a decrease in 1,25 dihydroxy vitamin D levels and the development of renal osteopathy, which is characterized by osteomalacia and osteitis fibrosa. This company’s assay development programme is focusing specifically on new vitamin D assays. After the recent launch of the 25-Hydroxyvitamin D Total RIA and ELISA assays based on patented monoclonal antibodies manufactured in-house, a new easy-to-use 1,25 dihydroxy Vitamin D ELISA is launched. This ELISA is specifically designed to be used manually as well as on open automated systems. As the total assay time is less than 6 hours, the patient’s results will be available the same day. The assay has been validated on the Stratec GEMINI open ELISA automated analyser (Stratec Biomedical GMBH – Germany) and a validated protocol will be made available to all Stratec GEMINI users.
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Analysis of CO2 is performed as part of an electrolytic analysis in the investigation of acid-base disorders, monitoring kidney disease (bicarbonate absorption function) or hypertension. In the body, 95% of CO2 is present as HCO3- (bicarbonate). Elevated or low levels of HCO3-may indicate a variety of disorders. The Carbon Dioxide Reagent is available in diff erent presentations, as well as Dioxide Standard and Carbon Dioxide Control.
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The automated parasite analysis system, Parasys, provides up to 4-fold greater sensitivity than the manual technique and in a fraction of the time. It standardizes laboratory protocol and morphology is improved, as new flow cell provides a 3D view of the organisms without the distortion that is usually created by the pressure of a coverslip. Lab staff gain health and safety benefits because they do not come into contact with hazardous samples or reagents.
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Testing for protein S plays an important role in thrombophilia screening. The INNOVANCE® Free PS Ag (protein S antigen) assay employs polystyrene particles coated with monoclonal antibodies for highly specific determination of free protein S. The assay demonstrates high linearity and excellent precision over the entire calibrated measuring range, as well as high specificity for free protein S antigens with no major interferences, including those commonly incurred from rheumatoid factors and heterophilic antibodies. The test delivers excellent reagent stability, superb lot-to-lot consistency and correlation of results among all the coagulation analysers on which it runs. The test’s ease of use minimizes operator training, and the liquid formulation requires no mixing or preparation, loading easily onto coagulation analysers.
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