A new generation of ELISAs provides standardized, automated analysis of beta-amyloid (Aß) peptides (Aß 1-42 and Aß 1-40) and total tau (T-tau) proteins in cerebrospinal fl uid (CSF), facilitating diagnosis of Alzheimer’s disease in its early stages. The concentrations of these biomarkers reflect the Alzheimer’s-specific neuropathological changes in the brain. A significant decrease in Aß 1-42 is observed as many as 5 to 10 years before the start of cognitive changes. Aß 1-40 remains unchanged. The determination of the ratio Aß 1-42 to Aß 1-40 increases the efficiency of early diagnostics and might help to discriminate Alzheimer’s disease from vascular dementia. The concentrations of T-tau and phosphorylated tau (P-tau) increase when patients develop advanced neurodegeneration and cognitive impairment. Th e Aß 1-42, Aß 1-40 and T-tau ELISAs have been developed by Euroimmun in collaboration with ADx Neurosciences. They are based on a sandwich principle employing well-characterized capture antibodies. This matrix-independent methodology ensures extremely high consistency in results. The assays are CE-certified and include lyophilized calibrators for added convenience and precision. The procedures are highly standardized and can be automated on Euroimmun analysers and other open ELISA platforms.
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The determination of Zinc in seminal plasma, together with the reagent for Citrate and Fructose complete the Biosystems line for the diagnostic evaluation of human fertility. Zinc is used as a marker of the secretory function of the prostate gland. Low values indicate an abnormal disruption of the secretory function, possibly as a result of obstruction of the conducts due to acute or chronic inflammation. The determination of zinc in serum provides information about the metabolism of proteins and nucleic acids, and the functioning of the immune system, which is required for wound healing. A severe blood zinc deficiency is linked with depressed growth and stunting and increases the incidence of infectious diseases. Less severe zinc deficiencies are linked with immune function disorder, diarrhea, altered cognition, alopecia, vision defects and other adverse clinical conditions. Ingestion of a zinc-contaminated diet involves high blood concentrations and is associated with abdominal pain, diarrhea and nausea. Heparinized plasma samples are preferred to serum for zinc analysis to avoid possible zinc contamination from erythrocytes, platelets and leukocytes during clotting and centrifugation.
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Entirely of human origin for in vitro cell culture applications, Lysex enables selection, expansion and differentiation of human primary cell cultures, such as adult and fetal mesenchymal stem cells (MSC), skin fibroblasts, articular chondrocytes, osteoblasts, adipose-derived cells. It enhances cell proliferation, maintaining the differentiation potential in cells otherwise difficult to expand in culture such as articular chondrocytes from elderly donors and allows culture of cells in a xeno-free environment (as it completely eliminates the need of fetal bovine serum). The fully standardized and lyophilized two-component system allows easy optimization of culture conditions for any cell type directly by the user.
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The Randox Homocysteine assay offers laboratories a convenient two-part, liquid ready-to-use option for the accurate determination of Homocysteine concentrations in serum or plasma.  Additional benefits associated with Randox Homocysteine include two levels of calibrator included in the kit for user convenience; limited interference helping ensure accurate and reliable results are returned; and an extensive measuring range of 1.74-47.9 µmol/l facilitating comfortable detection of abnormal levels related to all Homocysteine associated disease states. Furthermore, Randox Homocysteine is suitable for use on a variety of clinical chemistry analyzers via a range of instrument specific applications.

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The new Coapresta 2000 (CP2000) is an automated system with a small footprint, high-throughput and a range of dedicated barcoded reagents.  The system can run up to 400 PT tests per hour. Test panels include PT, APTT, Fibrinogen, D-dimer, FDP, AT and many other new assays are in development. The system offers excellent performance, predominately ready-to-use liquid reagents,  and can be interfaced to LAS systems using point- in-space sampling, which make it an exciting new choice for laboratories seeking an efficient, high performing coagulation solution. The system is the market leading product in the higher volume system category in Japan, where it was developed. The CP2000 Coagulation System is available for purchase in Europe, Middle East and Africa through the Sekisui Diagnostics offices in Kent, UK and Rüsselsheim, Germany as of January 2014.  
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