Clinical laboratory International (CLI)
The leading international magazine for Clinical laboratory Equipment for everyone in the in vitro diagnostics field and related disciplines.
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panglobal2026-01-15 09:36:492026-01-15 09:36:49Revvity unveils AI platform for molecular discovery
Anti-laminin β4 – a new autoantibody marker in pemphigoid disease
, /in Autoimmunity & Allergy, Featured Articles /by panglobalLaminin β4 (lamβ4) has been identified as a novel target antigen in anti-p200 pemphigoid, a rare autoimmune disease manifesting with subepidermal blisters. Anti-lamβ4 antibodies bind to the region of the dermal–epidermal junction and demonstrate pathogenic effects. A recombinant-cell indirect immunofluorescence assay has been developed for specific detection of anti-lamβ4 antibodies.
Identification of putative breath biomarkers for detection of lymphoma
, /in Featured Articles, Hematology & Flow Cytometry /by panglobalVolatile organic compounds (VOCs) are released from our bodies in our breath, sweat, blood and urine as a result of metabolic activity and so provide a window on our metabolic and physiological status. These VOCs change in response to disease, providing the potential for disease-specific VOCs in the breath to be used as non-invasive biomarkers […]
Point-of-care test for detection of the FKBP12 biomarker at single-molecule level
, /in Featured Articles, Rapid Tests & POC /by panglobalFK506 (tacrolimus) binding protein 12 (FKBP12) is involved in fundamental cellular processes as well as immunosuppression, neurodegenerative diseases and cancer. Hence, the ability to quickly and easily determine its levels is desirable. CLI caught up with Dr Pitruzzella, Dr Caminati and Prof. Cennamo to find out more about the point-of-care test that they have developed […]
Immune cell profiling and circulating tumour cell analysis can aid risk stratification and personalized decision-making in newly diagnosed multiple myeloma patients
, /in Featured Articles, Hematology & Flow Cytometry /by panglobalWhat is multiple myeloma? Multiple myeloma (also called myeloma) is the over-proliferation of abnormal plasma cells (which normally make antibodies) in the bone marrow (Figs 1&2).