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Johnson & Johnson to acquire Ambrx to advance nextgen antibody drug conjugates for cancer treatment

Johnson & Johnson has entered into a definitive agreement to acquire Ambrx Biopharma, a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform to design and develop next-generation antibody drug conjugates (ADCs), in an all-cash merger transaction for a total equity value of approximately $2 billion, or $1.9 billion net of estimated cash acquired.

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Biomarkers in heart failure | Beyond laboratory values

by Dr Roopa Rao and Arden Shen The incidence of heart failure (HF) is increasing globally. Biomarkers in HF play a key role in diagnosis and prognostication. Ideal biomarkers should be easily measurable with distinct values in normal physiology, disease state and be a marker of therapeutic intervention. Several biomarkers have emerged that are potentially […]

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Rapid detection of periprosthetic joint infections

By Dr Kyle H. Cichos and Dr Wilhelm Paulander This review examines periprosthetic joint infection (PJI) detection, highlighting the limitations of traditional methods and introducing isothermal microcalorimetry (IMC) as an innovative tool. IMC offers rapid, sensitive PJI detection, overcoming the challenges of culture-based and molecular diagnostics. Its potential applications in real-time monitoring, treatment efficacy, and […]

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Detection of cardiolipins using liquid chromatography-tandem mass spectrometry for diagnosis of Barth syndrome

By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]

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Development of a urine test for endometriosis

Endometriosis is an incurable, chronic condition, associated with debilitating pain and reduced fertility. It is thought to affect 190 million women worldwide and is associated with huge costs to the economy though loss of earnings and cost of health-care/treatment. Currently, diagnosis on average takes around 8 years. CLI chatted to Dr Barbara Guinn (Centre for […]

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NEWS RELEASE Beckman Coulter Diagnostics Appoints Kevin O’Reilly as New President

Beckman Coulter Diagnostics, a clinical diagnostics leader, today announced Kevin O’Reilly’s appointment as its new president succeeding Julie Sawyer Montgomery, who is now vice president and group executive at Danaher Diagnostics.  

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Getting the most from every drop – new advances in blood separation

Getting the most from every drop – new advances in blood separation Alexandra Sommer, Senior Product Manager, Clinical Diagnostics at Tecan

240107Feb OGT celebrates opening of new facility

OGT expands NGS operations to state-of-the-art facility in Oxford Technology Park Investment in new premises to create increase in cutting-edge genomic solutions and collaborative partnerships

OGT, a leading global provider of genomic research and diagnostic solutions, proudly announces the opening of state-of-the-art facilities within the Oxford Technology Park. The move represents a multi-million-pound investment, fuelled by consistent company growth and growing customer demand. 

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Total bile acids 21 FS – now applicable for human stool samples

DiaSys successfully introduced Total bile acids 21 FS to determine total bile acids (TBA) in serum. Now, without altering the reagent composition and the highly sensitive enzymatic cycling method, the scope of the test has been expanded to detect TBA in human stool samples.

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Anti-TBEV ELISAs for CSF and serum

EUROIMMUN has introduced CE-IVDR-compliant ELISAs for detection of IgG antibodies against tick-borne encephalitis virus (TBEV) in cerebrospinal fluid (CSF) and serum samples. TBEV causes the severe and potentially fatal neurological disease TBE, which is endemic in parts of Europe and Asia and is growing in range and incidence. In TBE cases with CNS involvement, detection […]