Apolipoprotein H (ApoH) is a major antigen for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS), which is related to venous and arterial thrombosis, fetal loss, and thrombocytopenia. Reports show that ApoH may function in blood coagulation and in the clearance of apoptotic bodies from circulation. Serum concentrations of ApoH have been found to be abnormal in patients with primary hyperlipidemia. Serum ApoH concentrations are increased in type 2 diabetes patients with microalbuminuria, suggesting a relationship with microvascular complications. ApoH was described as a major urinary protein in the urine of patients with renal tubular disorders such as Wilson´s disease, Dent´s syndrome, Fanconi´s syndrome and renal tubular acidosis. The Human ApoH ELISA kit extends BioVendor’s portfolio of diagnostic kits for lipoprotein metabolism, renal and cardiovascular disease and diabetology. Suitable for serum, plasma (EDTA, citrate, heparin) and urine samples, the 96 well-microtitre plate format is suitable for use with standard ELISA equipment.
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Six new assays have been added to the menu on Binding Site’s SPAplus Specialist Protein Analyser. These include IgG in cerebrospinal fluid (CSF), IgA CSF, IgM CSF, Albumin CSF as well as Transferrin in serum, and C1 inactivator (C1 inhibitor) in serum and plasma. All six assays are fully automated, easy to use and provide quantitative results to aid the assessment of a patient’s immune system (CSF assays), iron deficiency anaemia (transferrin) and the investigation of hereditary angioedema (C1 inactivator).The SPAplus is ideal for carrying out these specialist protein assays and has been designed to bring together instrument, reagents and exceptional support as a package from a specialist protein focused supplier.The analyser is a compact, turbidimetric platform for specialist protein testing. Its fully automated system enables laboratories to maintain the quality of results and high throughput required for specialised protein assays. It can be placed alongside the laboratory’s main-line analysers or in other areas of the laboratory. Pre-programmed protocols developed and manufactured by the company provide highly sensitive and reproducible results that match or have greater sensitivity than nephelometry. The modular design with intuitive Windows based software makes the analyser very easy to use. It is engineered to a high standard demonstrating excellent reliability with minimal daily, weekly and monthly maintenance procedures.
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IDEX Health & Science multiplies lab productivity with the first independent channel peristaltic pump for low volume, high precision applications. With individually addressable control of each fluidic channel, the new Ismatec ® Reglo ICC peristaltic pump eliminates the clutter of multiple pumps on the bench top and resolves application complexity. Long recognized in Europe as the gold standard of Swiss precision, Ismatec drives now power one, two, or three channels, each independently programmable from the pump or the computer to deliver continuous flow or precision aspiration and dispense with the added advantage of bi-directional flow on each channel. Visit www.WintheICC.com for information
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Manufactured and certified to ISO Guide 34, using ISO 17025 accredited processes in LGC’s own laboratories, the the LoGiCal range of certified reference materials offers scientists a choice of natural and deuterium labelled compounds, each supplied with a detailed Certificate of Analysis. The certified reference materials fully satisfy national and international labelling and other requirements for transportation, health and safety. The range focuses on the forensic and clinical sectors. Initially providing laboratories with access to over 800 of the most widely used standard reference materials, the new product range will comprise drugs of abuse and prescription drugs in standard solutions and powder format, with stocks maintained locally at LGC Standards international offices to help eliminate delays due to the complex, lengthy import procedures associated with the procurement of controlled substances.
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Automated test for homocysteine. An automated test for homocysteine is now available. The test is based on an enzymatic cycling method which
is adaptable to any clinical chemistry analyser. Homocysteine is a sensitive marker for folate and vitamin B12 deficiency and an independent risk factor for cardiovascular diseases. It has also been discussed in connection with other diseases such as birth defects, pregnancy complications, psychiatric disorders and cognitive impairment in the elderly. The standard method of measuring homocysteine has been by chromatography, which is time-consuming, complex and requires special equipment and skills. Other enzymatic assays show critical interference by cystathionine, which is often elevated in dialysis patients. The DiaSys Homocysteine FS is a liquid stable, ready to use reagent. The enzymatic cycling leads to significant enhancement of the substrate and therefore to stable signals and good precision. The test has a measuring range up to 50 µmol/L and is for use with serum or plasma. There is no interference from haemolysis, lipaemia and cystathionine, and it compares well with other methods. Liquid stable calibrators and controls are provided as well as instrument applications for various analysers.
Automated test for homocysteine
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