The prevalence of T2DM has reached epidemic levels, affecting about 7% of the U.S. population, and is growing. The Randox automated immunoturbidimetric adiponectin test offers an improved method for assessing T2DM risk, with a convenient format for routine clinical use. The Randox Adiponectin assay is available for use on most biochemistry analysers, including the RX […]
Circulating or tissue micro-RNAs and extracellular vesicles as potential lung cancer biomarkers: a systematic reviewSong Y, Yu X, Zang Z, Zhao G. Int J Biol Markers 2017; doi: 10.5301/ijbm.5000307 [Epub ahead of print] For both lung cancer patients and clinical physicians, tumor biomarkers for more efficient early diagnosis and prediction of prognosis are always wanted. […]
In the 1980s, cervical screening tests were introduced for the detection of abnormal cervical cells (the cytology-based Pap smear test). Since then there has been a reduction in the number of cervical cancer cases by about 7% each year. Under current guidelines in the UK, women are offered 12 tests per lifetime, with frequency based […]
Disease-associated variations in DNA methylation profiles hold significant potential for diagnostic and research applications. Unfortunately, scant and degraded samples often limit the analyses which can be performed. To overcome these issues, we developed Mass Spectrometry Minimal Methylation Classifier (MS-MIMIC) to identify then reliably analyse disease-specific DNA methylation profiles. The technique has now been validated in […]
Point-of-care glucose meters are used in a variety of settings to monitor glucose concentration in whole blood. Comparability between the results from these meters and results issued on plasma samples was examined by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), which in 2006 recommended that all glucose results should be reported as […]
Current emergency department strategies are aimed at reliably excluding myocardial infarction as soon as possible through clinical assessment and time-dependent measurement of high-sensitivity cardiac troponin. Point-of-care cardiac troponin methods have evolved, but can they be used to support the early rule-in or rule-out strategies for myocardial infarction? by Dr Martha E. Lyon and Dr Andrew […]
Biomarkers of diabetic nephropathy: A 2017 updatePapadopoulou-Marketou N, Kanaka-Gantenbein C, Marketos N, Chrousos GP, Papassotiriou I. Crit Rev Clin Lab Sci 2017; 54(5): 326–342Diabetic nephropathy (DN), also named diabetic kidney disease (DKD), is a devastating complication in patients with both type 1 and 2 diabetes mellitus (T1D and T2D) and its diagnosis has been traditionally […]
The need to differentiate patients with advanced liver disease from those with earlier stage, or more benign diseases for optimal management and allocation of resources is an ever present challenge. In this article we discuss our experiences of using the aspartate transaminase (AST) : alanine transaminase (ALT) ratio as part of a pathway to screen patients for […]
The digitalization of pathology is seen as a challenging but transformative process. It is one of the fastest growing areas in healthcare and Philips Digital Pathology Solutions is a pioneer and leader in this field. The technique creates digitalized slides from patient samples, allowing pathologists to review and share clinical data within seconds.Digital enhances overall […]
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