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Author Archive for: 3wmedia
Entries by 3wmedia
Lyme disease diagnosis: waiting for the next gold standard
Lyme disease is caused by Borrelia spirochaetes: predominantly Borrelia burgdorferi in North America (but also present in Europe), and predominantly B. afzelii and B. garinii in Europe and Asia and is spread to people via infected deer ticks. Infection occurs after only a minority of tick bites, but is typified by three stages. Stage 1, […]
Urine ethyl glucuronide and ethyl sulphate measurement using liquid chromatography-tandem mass spectrometry
Ethyl glucuronide and ethyl sulphate are ethanol metabolites that increase the time window for detecting recent alcohol intake in comparison to measuring breath or urine ethanol. These markers are a useful additional tool for monitoring individuals in alcohol dependence treatment programmes. To measure these analytes, liquid chromatography-tandem mass spectrometry methods have been developed that are […]
Use of an LC-MS/MS 13-steroid serum panel in the diagnosis of adrenocortical carcinoma
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly being used in clinical biochemistry laboratories to measure steroid hormones in order to overcome the issue of cross-reactivity that traditional immunoassays can be subject to. We have developed an LC-MS/MS method for the measurement of 13 steroids from a single blood sample, in order to improve the diagnosis […]
Automating LC-MS/MS analysis for streamlined clinical testing workflows
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology has emerged as an important tool for a wide range of analytical applications. However, the manual, multi-step processes involved in LC-MS/MS workflows have limited its adoption in clinical laboratories. In this article, we look at how the latest automated LC-MS/MS technology designed specifically for the clinical laboratory is simplifying […]
Use of immunohistochemistry in the determination of mismatch repair status of colorectal carcinoma
Microsatellite instability, reflective of a defective mismatch repair system, has been implicated as one of the main pathways involved in the pathogenesis of colorectal carcinoma. Herein, we describe the role of the mismatch repair system in the development of colorectal carcinoma, the advantages and disadvantages of using immunohistochemistry as the primary method of determining mismatch […]
Scientific literature review: Pathology
An assessment of the effect of haemoglobin variants on detection by faecal immunochemical tests Carroll MR, John C, Mantio D, Djedovic NK, Benton SC. Ann Clin Biochem 2018; doi: 10.1177/0004563218778716 [Epub ahead of print] BACKGROUND: Faecal immunochemical tests (FIT) for haemoglobin (Hb) are being used in the investigation of colorectal cancer. These tests use antibodies […]
Competitive PCR-high resolution melting analysis: an improved approach to assess BRCA status in hereditary breast and ovarian cancer patients
Widespread use of BRCA molecular testing has been observed in recent decades relating to the approval of PARP inhibitor as a target therapy for breast and ovarian cancer in BRCA-positive patients. This article provides an overview of the crucial issues of the BRCA test, focusing on our innovative cPCR-HRMA technology. by Elisa De Paolis, Dr […]
Winner of first global CARES HIV/AIDS award announced at IAS 2018
The award recognizes the ‘care, dedication and commitment’ of ordinary people in the battle against HIV/AIDS. A 28-year-old African community youth worker, Evah Namakula, has won the first, global CARES HIV/AIDS award, designed to recognize ordinary people who have shown ‘care, dedication and commitment’ in their communities as part of the fight against the disease. […]