Gentamicin is an aminoglycoside antibiotic that was discovered in the early 1960s. Its low cost and efficacy against Gram-negative bacteria (including many multidrug resistant ones), has made it a popular choice for treating serious infections and sepsis in adults and children. However, aminoglycoside antibiotics can be nephrotoxic and ototoxic. Although the nephrotoxicity seems to cause […]
Endometriosis is a common estrogen-dependent disease affecting approximately 176 million women worldwide. Presently, a blood test for endometriosis remains elusive with laparoscopic surgery followed by histopathological confirmation of lesions remaining the gold standard for diagnosis. Women with endometriosis experience long delays between the onset of symptoms and a definitive diagnosis. The search for single or […]
Point-of-care testing (POCT) is becoming an important part of laboratory medicine although instruments are not operated by laboratory personnel. In this study, we describe the planning and insertion of regulated policies for POCT and quality management, outside of the clinical laboratory. Our results emphasize the importance of the clinical laboratory department involvement to ensure accountable […]
Sepsis is a medical emergency that needs rapid identification and treatment to create the best possible outcomes. However, in the early stages it can be very difficult to distinguish sepsis from uncomplicated infection. This article summarizes recent developments in sepsis nomenclature and definitions as well as providing an insight into the role that biomarkers might […]
The increasing global burden of sepsis in healthcare calls for better diagnostic tests that allow earlier detection of sepsis and infections that could lead to sepsis. The major problem for patients at risk for sepsis is an immunological imbalance. Cells of the innate immune system, such as monocytes and neutrophils, are the first-line of defence […]
Extracellular vesicles as markers and mediators in sepsisRaeven P, Zipperle J, Drechsler S. Theranostics 2018; 8(12):3348–3365 Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a highly lethal condition in which current tools for early diagnosis and therapeutic decision-making are far from ideal. Extracellular vesicles (EVs), 30 nm […]
Standard drug testing is regularly carried out using urine, blood or oral fluid. However, fingerprints present a good alternative, as the sample collection is non-invasive, rapid and safe. Herein, we describe the application of two different testing methods for the detection of cocaine in fingerprint samples. by Dr Catia Costa, Dr Mahado Ismail and Dr […]
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