Modern ‘omics’ and screening technologies make possible the analysis of large numbers of proteins with the aim of finding biomarkers for individually tailored diagnosis and prognosis of disease. However, this goal will only be reached if we are also able to sensibly sort through the huge amounts of data that are generated by these techniques. […]
Mesothelioma is a fatal cancer of mesothelial cells caused by previous asbestos exposure. Numerous biomarkers have been tested for their ability to diagnose or monitor pleural mesothelioma, but none are in routine clinical practice. This article aims to briefly outline the literature to date and future research directions. by Dr David T. Arnold and Prof. […]
Antiepileptic drugs (AEDs) are widely used and their number is steadily increasing. Therapeutic drug monitoring of AEDs, when performed correctly, can be a valuable tool for the treating physician. This article describes the indications, limitations and pitfalls that must be observed when measuring and interpreting AED serum concentrations. by Dr Arne Reimers and Prof. Eylert […]
The continued use of first-generation antiepileptic drugs (AEDs) and their usually pronounced intra- and inter-individual variability, have made AEDs among the most common medications for which therapeutic drug monitoring (TDM) is performed. As the most cost-effective, rational and clinically useful methodologies are being pursued for TDM interventions, suitable sampling alternatives (e.g. dried blood samples and […]
Quantitative specific drug analysis by tandem mass spectrometry allows a wide range of drugs to be analysed in either urine or oral fluid to confirmation standards. The repertoire of drugs is based on drugs of abuse implicated in drug-related deaths in Scotland and currently includes 27 specific drugs and metabolites. by Dr Paul Cawood and […]
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