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Author Archive for: 3wmedia
Entries by 3wmedia
Towards earlier detection of ovarian cancer?
According to Cancer Research UK, the incidence of ovarian cancer in the UK is around 7500 new cases per year, accounting for 4% of all new cancer cases in females. The overall 5-year survival rate is around 46%, dropping to 35% at the 10-year mark, a relatively poor prognosis, but almost double that of 40 […]
Human epidermal growth factor receptor 2 (HER2) in colorectal carcinoma
ERBB2 gene amplification and HER2 protein overexpression occur in 2–5% of colorectal carcinomas and may predict response to targeted anti-HER2 monoclonal antibody therapies in patients with advanced disease. This article discusses the utility of next-generation sequencing and HER2 immunohistochemistry as biomarker assays for optimal selection of patients who may benefit from HER2 inhibitors. by Dr […]
Increased sensitivity of detecting and monitoring plasma cell disorders using MS
Plasma cell disorders are detected in the clinical lab by finding the monoclonal immunoglobulin (M-protein) they produce. Serum protein electrophoresis methods have been employed widely to detect and isotype M-proteins. Increasing demands to detect residual disease and new therapeutic monoclonal immunoglobulin treatments have stretched electrophoretic methods to their limits. Newer techniques based on mass spectrometry […]
Primary hyperoxaluria and measurement of relevant metabolites
by Felicity Stokes and Dr Gill Rumsby The primary hyperoxalurias are inherited disorders of urine oxalate overproduction that have significant morbidity and mortality. This article briefly reviews the three known disorders, their presentation, biochemical diagnosis and treatment strategies highlighting preanalytical and analytical issues raised with mass spectrometric methodologies.
LC-MS/MS in drugs of abuse testing for target screening and confirmation
Drugs of abuse testing is performed to identify drug abuse, to monitor someone with a substance abuse problem, or to detect drug intoxication and overdose. The identification of drug abuse in biological samples can be used in court as scientific evidence, and it can help to improve the quality of clinical management during emergencies. One […]
Introducing the SCIEX Citrine® MS/MS Medical Diagnostic (MD) mass spectrometer
In the modern diagnostic lab, analytical challenges demand increased sensitivity, speed, robustness and reliability of any diagnostic system, and mass spectrometry is no different. Designed and manufactured with industry-leading technologies, Citrine meets these challenges head on, giving confidence in results and the best possible service to patients. Citrine® MS/MS from SCIEX provides the ultimate performance […]