Researchers have identified a genetic signature for a severe, often painful food allergy – eosinophilic esophagitis – that could lead to improved diagnosis and treatment for children unable to eat a wide variety of foods. The scientists, from Cincinnati Children’s Hospital Medical Center that they have pinpointed a dysregulated microRNA signature for eosinophilic esophagitis (EoE), […]
Charles Eberhart, M.D., Ph.D. Johns Hopkins scientists have published laboratory data refuting studies that suggest blood vessels that form within brain cancers are largely made up of cancer cells. The theory of cancer-based blood vessels calls into question the use and value of anticancer drugs that target these blood vessels, including bevacizumab (Avastin). ‘We don’t […]
Researchers at Oregon State University have tapped into the extraordinary power of carbon ‘nanotubes’ to increase the speed of biological sensors, a technology that might one day allow a doctor to routinely perform lab tests in minutes, speeding diagnosis and treatment while reducing costs. The new findings have almost tripled the speed of prototype nano-biosensors, […]
A new JDRF-funded study shows that many of the genes known to play a role in type 1 diabetes (T1D) are expressed in pancreatic beta cells, suggesting that the cell responsible for producing insulin may be playing a part in its own destruction to lead to T1D. Researchers in Belgium suggest this interpretation after producing […]
To solve a modern health crisis, Jon Graff, MD, PhD, is looking back millions of years. Dr. Graff, Professor of Developmental Biology, and his colleagues genetically alter fruit flies to have diabetes or obesity. Jon Graff, MD, PhD: ‘We’re interested in unraveling the basis of metabolism,’ Dr. Graff said. ‘Our ability to control fat and […]
A team of researchers from the Hospital Universitario La Paz Research Institute (IdiPAZ, Madrid), LifeSequencing S.L. (Valencia), Era7 Bioinformatics (Madrid) and Roche Spain (Barcelona) announced on March 14th the sequencing of the whole genome of three antibiotic resistant strains of Klebsiella pneunomiae isolated from a recent outbreak in a Spanish hospital. The sequence data, generated […]
Women 65 or older who have even mild retinopathy, a disease of blood vessels in the retina, are more likely to have cognitive decline and related vascular changes in the brain, according to a multi-institutional study led by scientists at the University of California, San Francisco (UCSF). The findings suggest that a relatively simple eye […]
The addition of changes in inflammatory biomarkers to established clinical variables improves the prediction of mortality in patients with chronic obstructive pulmonary disease (COPD), according to a new study. ‘COPD is characterised by low-grade inflammation, so we hypothesised that the addition of inflammatory biomarkers to established predictive factors would improve the prediction of mortality,’ said […]
Widely used antibiotics may increase incidence and severity of allergic asthma in early life, according to a University of British Columbia study. The study shows that certain antibiotics that affect intestinal bacteria also had a profound impact on allergic asthma. ‘It has long been suspected that kids exposed to more antibiotics – like those in […]
Retinoic acid (vitamin A) and steroids are hormones found in our body that protect against oxidative stress, reduce inflammation and are involved in cellular differentiation processes. One of the characteristics of tumours is that their cells have lost the ability to differentiate; therefore these hormones have useful properties to prevent cancer. Currently, retinoic acid and […]
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