A research team from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and other institutions has discovered a new genetic target for potential therapy of sickle cell disease (SCD). The target, called an enhancer, controls a molecular switch in red blood cells called BCL11A that, in turn, regulates haemoglobin production. The researchers were led by Daniel […]
Extreme and traumatic events can change a person – and often, years later, even affect their children. Researchers of the University of Zurich and ETH Zurich have now unmasked a piece in the puzzle of how the inheritance of traumas may be mediated. The phenomenon has long been known in psychology: traumatic experiences can induce […]
A study, carried out on mice, has just confirmed the neurobiological origin of attention-deficit disorder (ADD), a syndrome whose causes are poorly understood. Researchers from CNRS, the University of Strasbourg and INSERM have identified a cerebral structure, the superior colliculus, where hyperstimulation causes behaviour modifications similar to those of some patients who suffer from ADD. […]
Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment. The test, called the cMethDNA assay, accurately detected the presence of cancer DNA in the blood of patients with metastatic breast cancers […]
The cause of neuronal death in Parkinson’s disease is still unknown, but a new study proposes that neurons may be mistaken for foreign invaders and killed by the person’s own immune system, similar to the way autoimmune diseases like type I diabetes, celiac disease, and multiple sclerosis attack the body’s cells. ‘This is a new, […]
Researchers from Yale School of Medicine and Celera Diagnostics have confirmed and extended the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. Thoracic aortic aneurysms, or bulges in the artery wall, can develop without pain or other symptoms. If they lead to a […]
Scientists have identified the first genetic variant specifically associated with the risk of a difficult-to-diagnose cancer sub-type accounting for around 10-15 per cent of all breast cancer cases. The largest ever study of the breast cancer sub-type, called invasive lobular carcinoma, gives researchers important clues to the genetic causes of this particular kind of breast […]
Large sections of the genome that were once referred to as ‘junk’ DNA have been linked to human heart failure, according to research from Washington University School of Medicine in St. Louis. Molecules now associated with these sections of the genome are called non-coding RNAs. They come in a variety of forms, some more widely […]
How to diagnose and manage Heparin-Induced Thrombocytopenia (HIT)? by Pr Yves Gruel – Professor of Hematology, Trousseau Hospital and University Francois Rabelais, Tours (France) Type II Heparin-Induced Thrombocytopenia (HIT) is an immune-mediated adverse effect of heparin treatment. Although rare, this complication can be serious and possibly life threatening. Approximately one third of hospitalized patients are […]
A new study from researchers at the University of Ottawa Heart Institute (UOHI), sheds light on a mysterious gene that likely influences cardiovascular health. After five years, UOHI researchers now know how one genetic variant works and suspect that it contributes to the development of heart disease through processes that promote chronic inflammation and cell […]
November 2024
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