Researchers from IMIM (Hospital del Mar Medical Research Institute) have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer. For the first time they have demonstrated the effects of the inhibition of this protein in mice suffering this type of cancer and the results showed an increase in survival of 20%. […]
Use of exome sequencing improved the ability to identify the underlying gene mutations in patients with biochemically defined defects affecting multiple mitochondrial respiratory chain complexes (enzymes that are involved in basic energy production), according to a study in the July 2 issue of JAMA. Defects of the mitochondrial respiratory chain have emerged as the most […]
Scientists have identified a set of 10 proteins in the blood which can predict the onset of Alzheimer’s, marking a significant step towards developing a blood test for the disease. There are currently no effective long-lasting drug treatments for Alzheimer’s, and it is believed that many new clinical trials fail because drugs are given too […]
Researchers at King’s College London have identified a genetic variant associated with an increased risk of stroke and heart attack. Stroke and heart attack are caused when arteries, already clogged up by fatty substances (a condition known as atherosclerosis), become completely blocked by the formation of a blood clot. Risk factors for this include smoking, […]
In many patients it is not easy to differentiate between the chronic inflammatory skin diseases psoriasis and eczema. Researchers at the Helmholtz Zentrum München and the Technical University of Munich (TUM) have now developed a procedure based on a skin analysis that enables an exact diagnosis to be made. In some patients, the chronic inflammatory […]
Researchers from Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and other centres have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. Knowledge of these mutations could potentially identify a greater number of patients with treatable mutations because many potent cancer drugs that […]
Scientists funded by the National Institutes of Health (NIH) have identified genetic markers associated with eosinophilic oesophagitis (EoE), an inflammatory disease characterized by high levels of immune cells called eosinophils in the oesophagus. Their findings suggest that several genes are involved in the development of EoE, which can cause difficulty eating and often is associated […]
Genetics could be the key to explaining nation’s levels of happiness, according to research from the University of Warwick. Economists at the University’s Centre for Competitive Advantage in the Global Economy (CAGE) have looked at why certain countries top the world happiness rankings. In particular they have found the closer a nation is to the […]
It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms. Now scientists from the Florida campus of The Scripps Research Institute (TSRI) have found in […]
University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn’s disease. The fundamental research points to a possible pathway for developing an effective therapy for the inflammatory bowel disease. The research was conducted […]
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