One of the central questions in human biology is to understand how our genes determine which diseases we get and how severe they might be. Knowing just the DNA sequence, or the blueprint, is not enough. We must figure out how proteins, the genes’ products, work too. Now an international team of researchers, jointly led […]
High blood pressure is a leading cause of death around the world, and its prevalence continues to rise. A study shows that a protein in the spleen called placental growth factor (PlGF) plays a critical role in activating a harmful immune response that leads to the onset of high blood pressure in mice. The findings […]
It’s known that cholesterol levels typically rise as people age and that high cholesterol levels are associated with increased risk of cardiovascular disease. What’s less known is that cholesterol levels begin to decline the more a person ages. Recently, researchers from the University of Texas Medical Branch at Galveston and the University of Kentucky found […]
Latest figures by the International Diabetes Federation (IDF) have shown that an average 20% of the GCC population and nearly 19% of the UAE population now live with diabetes, with a marked increase in type II diagnoses. Coupled with this rise in disease prevalence, the Health Authority Abu Dhabi (HAAD) is forecasting nearly fourfold increase of […]
New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes. This new study builds on previous research from this group showing that elevated blood levels of SNTF on […]
A study combining tumour cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer. The findings could lead to better tests for predicting whether a woman’s breast cancer will spread […]
Using next generation gene sequencing techniques, cancer researchers at UT Southwestern Medical Center have identified more than 3,000 new mutations involved in certain kidney cancers, findings that help explain the diversity of cancer behaviours. “These studies, which were performed in collaboration with Genentech Inc., identify novel therapeutic targets and suggest that predisposition to kidney cancer […]
After mining the genetic records of thousands of breast cancer patients, researchers from the Johns Hopkins Kimmel Cancer Center have identified a gene whose presence may explain why some breast cancers are resistant to tamoxifen, a widely used hormone treatment generally used after surgery, radiation and other chemotherapy. The gene, called MACROD2, might also be […]
Scientists from Uppsala University, the Science for Life Laboratory (SciLifeLab) in Stockholm and Uppsala University Hospital have developed a new method of rapidly identifying which bacteria are causing an infection and determining whether they are resistant or sensitive to antibiotics. ‘Clinical use of the method would mean that the right antibiotic treatment could be started […]
A class of drug for treating arthritis – all but shelved over fears about side effects – may be given a new lease of life following new research. The new study, led by Imperial College London, sheds new light on the 10-year-old question of how COX-2 inhibitors – a type of non-steroidal anti-inflammatory drug (NSAID) […]
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