Researchers on Mayo Clinic’s Florida campus have identified key differences between patients with sporadic amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) and those with the most common genetic form of ALS, a mutation in the C9orf72 gene. Their findings demonstrate that ALS patients show abnormalities in levels and processing of ribonucleic acids (RNA), biological […]
A database compiled by Ash Alizadeh and his team provides broad patterns that correlate with poor or good survival rates for a variety of cancers. Physicians have long sought a way to accurately predict cancer patients’ survival outcomes by looking at biological details of the specific cancers they have. But despite concerted efforts, no such […]
Researchers at the Aortic Institute at Yale have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care. Their work will also lead to the development of a “dictionary” of genes specific to the disease, according to researchers. Experts have known for more than […]
A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies. The role of mutations in […]
Australian researchers have used models to identify a potential link between excess production of inflammatory proteins that cause rheumatoid arthritis and the development of heart valve disease. The research team discovered that a critical inflammatory protein involved in rheumatoid arthritis could also lead to inflammation and disease of the heart valves, including aneurysms. The research […]
Scientists of the Comprehensive Pneumology Center (CPC) at the Helmholtz Zentrum München have identified a new mechanism which contributes to the development of idiopathic pulmonary fibrosis (IPF). They showed that the pathological changes of lung tissue are accompanied by an increase in protein turnover by the central protein degradation machinery of the cell – the […]
The functions of around 150 genes have been discovered by scientists across Europe in a major initiative to try to understand the part they play in disease and biology. Since mice share 90 per cent of their genes with humans they are one of the best organisms to help us understand human genetics. The European […]
New research from the University of Alberta shows that body fluids such as saliva may hold the keys to understanding a person’s likelihood of developing Alzheimer’s, even among those who don’t yet have memory and thinking problems associated with the disease. Knowing that Alzheimer’s typically coexists with certain metabolic disorders, Shraddha Sapkota, a neuroscience PhD […]
Cerebral palsy (CP) is the most common cause of physical disability in children. Every year 140 children are diagnosed with cerebral palsy in Quebec. It has historically been considered to be caused by factors such as birth asphyxia, stroke and infections in the developing brain of babies. In a new game-changing Canadian study, a research […]
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), in cooperation with colleagues at the University of Zurich and the Ruhr-Universität Bochum, have for the first time successfully tested a new tumour diagnosis method under near-real conditions. The new method first sends out an antibody as a ‘spy’ to detect the diseased cells and then binds to them. […]
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