Many cancers include increased copies of the gene MET. But in which cases is MET driving the cancer and in which do these increased copies happen to ‘ride along’ with other molecular abnormalities that are the true cause of the disease? The answer influences whether a tumour will respond to drugs that inhibit MET, like […]
Researchers from the University of Ottawa Heart Institute (UOHI), together with the teams of Dr. Martin Farrell at Oxford University, and Dr. Sekar Kathiresan at the Broad Institute, have found the answer to an ongoing debate in the cardiovascular scientific world. Dr. Ruth McPherson and Dr. Majid Nikpay, researchers at the UOHI’s Ruddy Canadian Cardiovascular […]
Gastric cancer poses a significant health problem in developing countries and is typically associated with late-stage diagnosis and high mortality. A new study points to a pivotal role played by the biomarker microRNA (miR)-506 in gastric cancer. Patients whose primary gastric cancer lesions express high levels of miR-506 have significantly longer survival times compared to […]
Scientists at Karolinska Institutet and Karolin ska University Hospital in Sweden have discovered a new explanation for severe early infant epilepsy. Mutations in the gene encoding the protein KCC2 can cause the disease, hereby confirming an earlier theory. Through large-scale genetic analyses of a family with two affected children at SciLifeLab in Stockholm , mutations […]
An international team that includes researchers at Sahlgrenska Academy has found a new genetic cause of osteoporosis. The findings set the stage for eventually curing the disease. Osteoporosis is a common condition that leads to fractures with half of all women experiencing a fracture during their lifetime. The discovery of a genetic variant has permitted […]
29 September 2015, Darmstadt, Germany — Merck Millipore, the Life Science division of Merck, accepted a Silver Stevie® Award for its AFS® E Water Purification Systems at a banquet held on Friday, September 11 in San Francisco. The award was conferred by The American Business AwardsSM, the premier business awards program in the United States. […]
A few years ago, Javier Benítez, director of the Human Genetics Group at the CNIO, received a call from Pablo García Pavía, from the Cardiology Unit of the Puerta de Hierro University Hospital. This cardiologist was treating two brothers with a rare form of cancer, cardiac angiosarcoma (CAS). Could the experts in genetics do something? […]
A group of researchers, led by Prof. Matozaki Takashi and Associate Prof. Murata Yoji at the Kobe University Graduate School of Medicine Division of Molecular and Cellular Signalling, were the first to demonstrate the role of stomach cancer–associated protein tyrosine phosphatase (SAP)-1 in the pathogenesis and prevention of Crohn’s disease, ulcerative colitis, and other inflammatory […]
Unravelling the genetic sequences of cancer that has spread to the brain could offer unexpected targets for effective treatment, according to new research. Researchers say that they found that the original, or primary, cancer in a patient’s body may have important differences at a genetic level from cancer that has spread to the patient’s brain […]
The UK10K study explored the contribution of these rare genetic variants to human disease and its risk factors. Rare genetic variants are changes in DNA that are carried only by relatively few people in a population. The UK10K study was designed to explore the contribution of these rare genetic variants to human disease and its […]
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