Researchers funded by the National Institutes of Health have discovered the cellular switch that boosts the activity of sperm cells so that they can travel to the egg. The finding may lead to new options for male contraception as well as treatments for infertility resulting from problems with sperm mobility. Inside the male reproductive tract, […]
Demonstrating the potential of precision medicine, an international study based at UT Southwestern Medical Center used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). Precision medicine is an emerging field that aims to deliver highly personalized health care by understanding how individual differences in […]
New light has been shed on the genetic relationship between autistic spectrum disorders (ASD) and ASD-related traits in the wider population, by a team of international researchers including academics from the University of Bristol, the Broad Institute of Harvard and MIT, and Massachusetts General Hospital (MGH). The researchers studied whether there is a genetic relationship […]
A global study involving 50 different research centres has found hundreds of genes which cause five common, hard-to-treat and debilitating inflammatory diseases, paving the way to new treatments for these conditions. Led by Brisbane’s QUT and Christian-Albrechts-University, Kiel, Germany, the results of the world-first study have been published. Co-senior author Professor Matthew Brown, from QUT’s […]
Researchers at the University of Southampton have discovered specific markers on DNA that link the season of birth to risk of allergy in later life. The season a person is born in influences a wide range of things: from risk of allergic disease, to height and lifespan. Yet little is known about how a one-time […]
An international consortium of researchers, led by a team at the Wellcome Trust Sanger Institute, has discovered conclusive evidence for the involvement of a gene called SETD1A in schizophrenia. Damaging changes to this gene, which occur rarely, increase the risk of schizophrenia 35-fold and also increase risk for a wide range of neurodevelopmental disorders. The […]
At age 56, Roma Jean Ockler was continually afflicted with sinus infections and pneumonia, and despite treatments, only seemed to be getting worse. For decades, immunologist Harry R. Hill, M.D., had seen patients like her. At the time he couldn’t have known that her family’s genetic information, combined with that of five other families from […]
Together with AIDS, tuberculosis ranks among those infectious diseases with the highest global mortality rate, claiming the lives of between 1.5 and two million people every year. However, not everyone infected with the bacterium develops tuberculosis. In fact, fewer than ten percent of those infected go on to manifest the disease. An international team of […]
Researchers from Massachusetts Eye and Ear and Schepens Eye Research Institute have shown an association between a defective myogenic response — the regulatory increase or decrease in blood pressure to keep blood flow within the vessels of the retina constant — and early, accelerated development of retinopathy in patients with type 1 diabetes. These findings […]
The genomes of two distinct strains of the virus that causes the common lip cold sore, herpes simplex virus type 1 (HSV-1), have been identified within an individual person — an achievement that could be useful to forensic scientists for tracing a person’s travel history. The research also opens the door to understanding how a […]
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