Immunocompromised hosts are at special risk for invasive fungal infections (IFI). Traditional methods of diagnosis (e.g. culture and molecular methods) largely suffer from poor sensitivity, thus limiting their clinical utility. Enzyme immunoassay-based detection of fungal antigens represents an attractive, supplementary method for IFI identification and is the focus of this review. by Phillip R. Heaton […]
Clinical microbiology laboratories were central to the tough but successful fight against infectious diseases in the 19th and first half of the 20th centuries, and resonate in the names of now-iconic figures from Jenner, Pasteur and Lister to Koch, Gram and Fleming.
Whipple´s disease, a systemic and ultimately fatal infection with Tropheryma whipplei, is usually easily treated if diagnosed early enough. A novel real-time PCR protocol and fluorescence in situ hybridization provide an improved diagnosis. All results, however, need careful interpretation. We recommend involving specialized centres in the initial diagnosis and patient follow-up. by Alexandra Wießner, Dr […]
Infection with Helicobacter pylori is indicated in disorders of the upper gastrointestinal tract, from dyspepsia and ulcer disease to gastric carcinoma. It can be detected during endoscopy or non-invasively using breath, stool or blood samples, each of which has advantages and limitations depending on patient and population circumstances. by Sarah Knowles and Julia M. Forsyth […]
Clostridium difficile is a major cause of nosocomial infections and rapid diagnosis of the disease is essential for infection control. Several methods for C. difficile detection are employed in clinical laboratories; each method has its advantages and disadvantages. A novel method has recently been developed that allows differentiation between C. difficile-positive and -negative stool samples […]
Although Helicobacter cinaedi infection is now recognized as an increasingly important emerging disease in humans, it is difficult to identify particular isolates due to their unusual phenotypic profiles and similarity of 16S rRNA sequences among closely related helicobacters. MALDI-TOF MS resolved the present difficulties associated with the identification of H. cinaedi. by Takako Taniguchi and […]
A new, benchtop molecular analyser allows renal transplant centres to monitor urine and serum BK viral loads in house, permitting earlier diagnosis and management of BK virus associated nephropathy (BKVAN) in renal transplant recipients. BK virus infectionNamed after the renal transplant patient (with initials B.K.) that it was first isolated from in 1971, BK virus […]
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