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Tag Archive for: Laboratory

Laboratory

Posts

Shimazdu online TOC analyzer

Shimadzu releases online TOC analyzer designed for pure water applications

Laboratory, 11 May 2021/in Product News /by panglobal

Shimazdu online TOC analyzer

 

The first analyzer in the world to use an excimer lamp /
Minimum footprint, highly sensitive, environment-friendly /
Targeting precision manufacturing, pharmaceuticals, semiconductors

Shimadzu, one of the world leaders in analytical instrumentation, has released the TOC-1000e, the first analyzer in the eTOC series of on-line TOC analyzers designed for pure water applications. The eTOC series’ main focus is on miniaturization, high sensitivity and a mercury-free oxidation technique. The pioneering TOC-1000e system has the world’s smallest and lightest cabinet and provides high-sensitivity detection, making it ideal for fields requiring high-purity water applications. This covers manufacturing, including pharmaceuticals, semiconductors, food & beverages, chemistry and precision equipment.

Total organic carbon (TOC) analyzers are used to rapidly quantify organic substances in water, allowing decisive process intervention. Among many fields of application, they are used mainly for water quality control and environmental investigations. Shimadzu’s world-leading TOC analyzers are well-suited to laboratory and on-line analysis of environmental and waste water. The eTOC series will be Shimadzu’s first on-line TOC analyzer designed especially for pure water measurements.

Minimum footprint, highly sensitive, environmental-friendly

The TOC-1000e provides enhanced robustness in the ultra-low measurement range. With its small footprint of less than A4 size, it can be installed flexibly – either as table-top, wall-mounted or pole-mounted.

Conventional TOC analyzers for pure water utilize mercury UV lamps as the light source within the instrument. To provide a more environmental-friendly alternative, the eTOC series is the first analyzer in the world to use an excimer (short for ‘excited dimer’) lamp rather than a mercury lamp.

The “Active-Path” flow line design maximizes lamp power by integrating the sample flow channel and the light source. This minimizes sample residue in the flow channel and eliminates interfering air layers, so high sensitivity is maintained over long-term use. This new design also contributes to making the eTOC series instruments small and light.

Features

The TOC-1000e combines high-sensitivity and easy-to-use features benefiting effortless data management, efficiency and handling.

Some of the features include:

  • State-of-the-art oxidation technology in the smallest casing
    The TOC-1000e provides high sensitivity with a detection limit of 0.1 μg/L. It is housed in the world’s smallest and lightest cabinet and equipped with the industry’s largest color touch panel, providing exceptional visibility, simplifying operation and allowing effortless management of compliance relevant data. In addition, the novel fluid system minimizes sample residue in the flow channel, ensuring that high sensitivity is maintained.
  • Easy-to-use and to maintain design improves efficiency
    The eTOC series has a simple design, and parts typically do not need to be replaced for one year; this increases efficiency by reducing maintenance and re-validation effort. Consumable parts (excimer lamp and pump head) can be removed and installed without tools. Using an optional sampler, the analyzer can be calibrated or validated (confirmation of manufacturing process validity) at the operating site. Certified standard solutions particularly for this series are available; they save customers the time and expense of purchasing and preparing items from a reagent manufacturer, and reduce mistakes caused by human error. In addition to analog interface and digital I/O, measurement data can be output to a printer or USB flash drive, or browsed and acquired via a built-in web server.
  • Support for Regulatory Compliance
    eTOC’s highly sensitive UV oxidation-conductivity method for ultra-pure water monitoring is compliant with regulatory requirements such as the United States (USP) and the European Pharmacopeia (EP). Inbuilt security functions including user authentication and audit trail, support compliance with regulations such as FDA 21 CFR Part 11. The LabSolutions software platform provides integrated management of the measurement data together with data and electronic signature functions (ER/ES) from laboratory TOC analyzers and other analytical instruments.

For more information, visit: https://www.shimadzu.eu/toc-analysis/etocseries

https://clinlabint.com/wp-content/uploads/sites/2/2021/05/Shimadzu_TOC_web.jpg 1134 1701 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-05-11 12:44:292021-05-11 12:49:48Shimadzu releases online TOC analyzer designed for pure water applications
Vyon porous plastic discs

Porvair’s hydrophilic porous plastic components offer cutting-edge filtration

Laboratory, 3 May 2021/in Product News /by panglobal

Vyon porous plastic discs

Vyon porous plastic discs and annular absorbers manufactured to extremely tight tolerances by Porvair Sciences offer cutting-edge filtration and separation of materials for healthcare, pharmaceutical and life science applications.

Drawing upon a wealth of knowledge in the manufacture of industry-leading porous plastics, combined with advanced materials expertise, Porvair Sciences has established a reputation for delivering outstanding hydrophilic components to OEM customers worldwide.

Employing precision moulding and die cutting processes, Porvair Sciences can efficiently convert hydrophilic Vyon® porous plastic into discs and annular shaped parts to tightly toleranced specifications. These versatile approaches enable Porvair to offer high performing, precisely manufactured products in diameters ranging from 3 mm to 1 metre using any of its hydrophilic Vyon materials options up to 4.75 mm thick.

Hydrophilically-treated Vyon materials have exceptional absorption and fluid transfer properties and therefore, can be implemented as an efficient absorber with its instantaneous wetting properties.

Due to the tortuous path of its porous structure, hydrophilic Vyon can efficiently filter and trap contaminants while allowing for effective delivery of drugs in various forms like solutions, suspensions and emulsions.

Hydrophilic Vyon has been tested to the most rigorous of USP classes and certified with a Class VI approval. Widely used in drug delivery and rapid diagnostic testing applications, its biocompatibility makes Vyon the ideal porous plastic material for healthcare, life science and pharmaceutical applications.

  • For more information, visit: www.vyonporousplastics.com/material-treatments/
https://clinlabint.com/wp-content/uploads/sites/2/2021/05/vyon.jpg 844 1168 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-05-03 12:58:052021-05-03 12:58:05Porvair’s hydrophilic porous plastic components offer cutting-edge filtration
new pHelper-Kan plasmid DNA

AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus manufacturing

Laboratory, 3 May 2021/in Product News /by panglobal

new pHelper-Kan plasmid DNA

Manufactured in dedicated clean-rooms with mandated changeovers before new production cycles – AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus (AAV) manufacturing.

Adeno-associated virus is a non-enveloped virus that can be engineered to efficiently deliver DNA sequences of interest into target cells with a low immunogenicity. Because of these unique characteristics, AAV-mediated genome editing has emerged as a highly promising gene delivery method.

The robust virus packaging productivity of this pHelper-Kan plasmid has been tested in almost all AAV serotypes. pHelper-Kan is proven for use in daily AAV production, for both GMP grade and research grade batches.

Immediately available, premanufactured in stock, AMSBIO pHelper-Kan plasmid reduces the optimization work required to obtain high efficacy when producing viral vectors. The high reproducible quality of the pHelper-Kan plasmid DNA is maintained and verified by the company’s standardized manufacturing technology.

AMSBIO also provides a custom service to make ready-to-use AAV for any specific gene, shRNA or miRNA. Working closely with customers, AMSBIO will sub-clone your selected genes into their AAV expression vectors and produce expression AAV for each gene.

  • Visit https://www.amsbio.com/aav
  • For further information on the pHelper-Kan plasmid DNA, visit:
    https://www.amsbio.com/phelper-kan-gmp-readytm-helper-plasmid-for-aav-packaging-gr-phelper-kan-v1

 

https://clinlabint.com/wp-content/uploads/sites/2/2021/05/amsbiopr287.jpg 960 1440 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-05-03 12:47:492021-05-03 12:47:49AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus manufacturing
PhysioMimix OOC multi-organ microphysiological system

CN Bio introduces the PhysioMimix OOC multi-organ microphysiological system

Laboratory, 3 May 2021/in Product News /by panglobal
PhysioMimix OOC multi-organ microphysiological system

CN Bio’s PhysioMimix OOC multi-organ microphysiological system.

CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), has launched its new PhysioMimix™ OOC Multi-Organ MPS. The next-generation platform combines CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to more accurately recapitulate the multi-organ and systemic effects observed in humans.

Demonstrating a key milestone in the Company’s mission to develop the most complete human ‘body-on-a-chip’ in the laboratory, the PhysioMimix OOC Multi-Organ MPS will provide advanced insights into the potential effects of novel therapeutics that were previously only achievable using animal models.

CN Bio’s Multi-Organ MPS enables researchers to generate sophisticated in vitro models that better represent human inter-organ crosstalk effects compared to single-organ MPS, or animal models. This system can be used to decrease the risk of clinical trial failures due to cross-species translational differences and can be used in the development of new human-specific modalities for which animal models are unsuited.

The Company’s advanced 3D liver model can be reliably and easily interconnected with other organs (such as gut, lung or kidney) to provide a human in vitro alternative to animal or in silico first pass metabolism studies (ADME), to elicit a deeper human-specific mechanistic understanding of disease states and to identify reactive metabolite-driven toxicity or multi-organ toxicity. Furthermore, in vitro to in vivo clinical predictions can be extrapolated using Physiologically-Based Pharmacokinetics (PBPK) mathematical models, to increase the accuracy and precision of data translation. For existing PhysioMimix users, an upgrade path is available.

Prior to launch, the system has undergone extensive internal and external validation by the University of Pittsburgh, and by a major pharmaceutical company.

Inherent biological differences

“The inherent biological differences of animal models with human physiology frequently result in the misrepresentation of pharmacological processes, contributing to the large proportion of new medicines that fail in clinical trials. Furthermore, in certain scenarios, animal models are unsuitable for efficacy and safety evaluation due to their genetic and immunological differences,” said Dr David Hughes, CEO, CN Bio.

“Our new multi-organ platform addresses the needs of a wider customer base, whilst providing the same ease-of-use, robustness, and reliability as the single-organ system which has been on the market since 2018. This launch extends CN Bio’s reach from world-leading provider of single-organ-on-a-chip technologies into multi-organ-on-a-chip, as we strive to expand the boundaries of humanized pre-clinical research and development.”

Professor Alan Wells, Professor of Pathology, Integrative Systems Biology Department, University of Pittsburgh, said: “The pathobiology of disease, even if limited to one organ, does not occur in isolation to the rest of the body. To understand how other events affect the pathology in question requires their constant communication. We are finding these networks key to tumour progression in metastatic sites, to address the Achilles heel of cancer therapy.”

  • For future details on the PhysioMimix OOC range, now comprising the PhysioMimix Single-Organ and PhysioMimix Multi-Organ Systems, visit: https://cn-bio.com/physiomimixooc/

 

 

https://clinlabint.com/wp-content/uploads/sites/2/2021/05/PhysioMimix.png 726 938 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-05-03 12:38:502021-05-03 12:38:50CN Bio introduces the PhysioMimix OOC multi-organ microphysiological system
Thermo_scientific centrifuges

Thermo Fisher Scientific expands Pro Centrifuge series with 2 new models

Laboratory, 26 April 2021/in Product News /by panglobal

Thermo_scientific centrifuges

Thermo Fisher Scientific has expanded its Thermo Scientific General Purpose Pro Centrifuge Series with the addition of two new models designed to meet the needs of biopharmaceutical, cell and gene therapy, and academic research laboratories, as well as clinical diagnostic facilities, for enhanced sample safety and reproducibility, improved ergonomics and reduced noise levels.

The new 1.6 L benchtop and 4 L floor-standing systems complete the General Purpose Pro Centrifuge Series, completing a comprehensive family of products to address varying sample capacity and laboratory space requirements. Like the other systems in the series, the new models feature a unique full colour, glass touchscreen display that facilitates a simple user interface for immediate, effortless workflow and operation monitoring, as well as easy cleaning.

A new high-speed rotor complements the 4 L models providing the ability to run both microplates and tubes. Built with versatility in mind, the complete General Purpose Pro Centrifuge Series offers 24 different rotor options in total — including 11 swinging bucket and 13 fixed angle rotors — which can be used interchangeably to align with various application needs, from cell culture procedures and microplate processing to cell and gene therapy manufacturing and clinical protocols. The systems’ ergonomically enhanced, novel industrial design enables the quick and safe change of any of the 24 rotor types in just three seconds through the Auto-Lock Rotor Exchange function.

The General Purpose Pro Centrifuge Series includes the Thermo Scientific Sorvall, Thermo Scientific Multifuge and Thermo Scientific Megafuge systems, all of which meet the latest global IVD standards and medical regulations. Superior sample capacity and performance are enabled through the systems’ Fiberlite Carbon Fiber Rotors, while the certified ClickSeal Biocontainment Lids ensure personnel and laboratory environment safety and security.

  • For more information, visit: Thermo Scientific General Purpose Pro Centrifuge Series
https://clinlabint.com/wp-content/uploads/sites/2/2021/04/Thermo-Scientific2.jpg 850 1134 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-26 15:33:102021-04-26 15:33:10Thermo Fisher Scientific expands Pro Centrifuge series with 2 new models
HER2 cell line array

AMSBIO introduces HER2 cell line array for breast cancer research

Laboratory, 26 April 2021/in Product News /by panglobal

HER2 cell line array

AMSBIO has introduced a new HER2 control cell line array that is proven as an effective slide quality control for HER2 expression in breast cancer tissue samples.

This new FFPE cell pellet microarray delivers a full dynamic range of HER2, ER and PR expression, validated by the Ventana system, to give immunohistochemical data in strong concordance with the routinely processed tissue sample sections.

Using cell line controls significantly lower the costs of immunohistochemical (IHC) examinations and fluorescence in situ hybridization (FISH) while enabling high levels of standardization and reliability.

AMSBIO offer a wide range of high quality FFPE cancer cell line controls for researchers. Manufactured using a proprietary process that maintains both cell morphology and preserves nucleic acids and proteins, the AMSBIO range of FFPE cancer cell line products offer affordable and consistent controls from 100 tumor cell lines, without compromising quality or consistency. These cell line controls combat issues experienced with traditional cell or tissue-based control specimens such as intra specimen variation, lot-to-lot variations and inconsistent biomolecule quality. FFPE controls provide the most flexible cell-based products for immunohistochemistry, in situ hybridization and next generation screening applications.

For more information, visit: https://www.amsbio.com/ffpe-cancer-cell-line-controls/

https://clinlabint.com/wp-content/uploads/sites/2/2021/04/amsbio_HER2.png 584 704 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-26 15:10:392021-04-26 15:10:39AMSBIO introduces HER2 cell line array for breast cancer research
SARS-Cov_2 variants of concern - assays from Bio-Rad

Bio-Rad launches SARS-CoV-2 variant RT-PCR assays

Laboratory, Virology, 23 April 2021/in Product News /by panglobal

SARS-Cov_2 variants of concern - assays from Bio-Rad

Bio-Rad Laboratories has introduced SARS-CoV-2 Variant RT-PCR Assays for research use only (RUO). The assays can detect SARS-CoV-2 variants of concern, including P.1, B.1.351, and B.1.1.7, by distinguishing specific mutations using reverse transcription PCR (RT-PCR) often prior to a next generation sequencing (NGS) workflow for confirmation.

With the emergence of several SARS-CoV-2 variants of concern, public health researchers are looking for a quicker way to track the spread of these variants in a population. Laboratories that use NGS to track COVID-19 variants can detect these mutations more quickly and cost-effectively with the SARS-CoV-2 Variant RT-PCR Assays to more rapidly prioritize which samples to submit for NGS.

  • For more information, visit: bio-rad.com/COVIDVariantSurveillance
https://clinlabint.com/wp-content/uploads/sites/2/2021/04/SARS_CoV_2_genetics.jpg 425 850 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-23 09:14:372021-04-23 09:14:37Bio-Rad launches SARS-CoV-2 variant RT-PCR assays
total RNA extraction by Porvair Sciences

Porvair Sciences launches kits for rapid extraction of total RNA

Laboratory, 23 April 2021/in Product News /by panglobal

total RNA extraction by Porvair Sciences

Porvair Sciences has launched new kits for rapid extraction of total RNA from a wide range of biological samples. These proprietary kits enable extraction of up to 1000 µg of application-ready pure RNA in as little as 10 minutes.

Extraction and purification of  RNA is required for numerous downstream molecular biology applications such as RT-PCR, qPCR, Western blotting and RNA amplification. The global COVID-19 pandemic has resulted in a huge increase in the demand for testing and detection of viral nucleic acids. The first step in this process, no matter what research or testing method is to be used, is to extract the RNA from any sample with a potential viral contamination.

The new affordable and easy-to-use Chromatrap RNA Extraction kit from Porvair Sciences all follow the simple procedure of  sample lysis, RNA capture, washing, and finally elution of purified RNA.

Leveraging a uniquely designed spin column and proprietary buffer chemistry, the Chromatrap RNA Extraction kit is the complete solution for isolation and purification of RNA. Providing the perfect high recovery of top-quality salt and contaminant-free RNA.

Porvair’s extraction kits employ a reliable protocol to isolate superior quality RNA from a wide range of samples sources. These kits benefit from high volume binding capacity which ensures RNA is efficiently lysed, captured and eluted.

The Chromatrap RNA Extraction kit is quick and easy to use, ensuring high recovery of high purity RNA during the first steps of fundamental molecular biology applications. Using a Chromatrap RNA extraction kit – scientists are now able to process up to 107 cultured animal cells, 50 mg animal tissue, 0.5 ml blood, 250 mg plant material, 5 x 107 yeasts or 5 x 108 bacteria in a single go.

  • For more information, visit: chromatrap.com/chromatrap-rna-extraction-kit/
https://clinlabint.com/wp-content/uploads/sites/2/2021/04/rna.jpg 957 850 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-23 09:06:172021-04-23 09:06:17Porvair Sciences launches kits for rapid extraction of total RNA
AMSBIO offers animal-free enzymes for in-vitro tissue dissociation

AMSBIO offers animal-free enzymes for in-vitro tissue dissociation

Laboratory, Research, 6 April 2021/in Product News /by panglobal

AMSBIO offers animal-free enzymes for in-vitro tissue dissociationAMSBIO, in association with Nordmark Biochemicals, is now offering animal-free Collagenase and Neutral Protease enzymes, isolated from Clostridium histolyticum, for in-vitro tissue dissociation leading to high yields of viable cells.

Being animal-free, these enzymes are very safe and offer reduced regulatory hurdles for use in clinical applications. They are manufactured under GMP guidelines using a plant-based production process that guarantees no risk of cross-contamination with animal-derived materials. These top-quality enzymes can be used on a wide range of cell/tissue types and are supported with specific protocols available based on each application.

Highly consistent, top quality Collagenase and Neutral Protease are essential tissue dissociation enzymes for tissue engineering and regenerative medicine applications. In addition to the animal-free enzymes, this product portfolio includes a comprehensive range of Collagenase and Neutral Protease enzymes manufactured under GMP guidelines with certified TSE safety and virus validation studies carried out for each batch. The high level of quality control involved in the production of these enzymes means that they have reliable lot-to-lot consistency with accurate analysis of proteolytic enzyme activities.

AMSBIO also offers research grade Collagenase and Neutral Protease enzymes. These research grade enzymes are available with a wide range of enzymatic activities, from standard collagenases, offering balanced amounts of other proteolytic activities, to highly purified collagenases. As each application requires different digestion conditions, this large range of Collagenase NB products offers optimal digestion conditions for a wide variety of tissue types.

To help you find the right enzyme and specific protocol best suited to your choice of cells and tissues, and thereby ensure consistent optimized results, AMSBIO has established an online resource at: https://www.amsbio.com/collagenase-nb-and-neutral-protease/.

https://clinlabint.com/wp-content/uploads/sites/2/2021/04/amsbiopr288.jpg 1036 1364 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-06 10:34:072021-04-06 10:34:07AMSBIO offers animal-free enzymes for in-vitro tissue dissociation
Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator

Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator

Laboratory, Research, 6 April 2021/in Product News /by panglobal
Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator

Porvair Sciences’ Ultravap Levante nitrogen blowdown sample evaporator

Porvair Sciences has launched its new generation Ultravap Levante nitrogen blowdown sample evaporator.

The second generation system offers the many benefits associated with Porvair’s flagship evaporator, the Ultravap Mistral, in an affordable, easy-to-use package. This state-of-the-art single microplate evaporator is designed to meet the current needs of most chromatography laboratories whilst providing the future option of fully automating sample dry-down in applications such as LC/MS analysis, dry recovery or reconstitution.

The compact, standalone Ultravap Levante is fully programmable and easy to control from a robot liquid handler. Its advanced head technology enables delivery of evaporation temperatures up to 80°C for faster  solvent evaporation rates. If required the system has the option to be fitted with ducted fan fume extraction.

Operated via an intuitive graphical colour LED touchscreen, software features includes up to 5 stored alphanumerically named programs and multi-step evaporation programs. This functionality combined with real-time run displays showing actual gas temperature, gas flow rate and stage height means the Ultravap Levante puts you in full control of the evaporation process. A removable acrylic splash guard safeguards the operator and also ensures efficient removal of the solvent vapour from the evaporation table.

The Ultravap Levante is supplied with an evaporator head of your choice, which may be interchanged quickly and easily with a head of a different pattern as your workflow demands.

The precision engineered mechanism uses a standard ANSI/SLAS plate nest to accept most microplate formats and tube racks. It can accommodate tubes up to 50 mm in height in a variety of configurations to allow the use of 2 Dram vials, 1.5 ml HPLC vials, bar-coded tubes in racks and many other common formats. Evaporator heads are available for efficient dry down of 24-, 48-, 96- and 384-well microplates at temperatures up to 80°C

The Ultravap Levante can be operated from both a gas cylinder and an in-house supply of nitrogen or clean dry air. The blow-down evaporation technique is well proven for efficiently removing chromatography solvents such as dichloromethane, acetonitrile, methanol and hexane.

  • For more information, visit: https://www.microplates.com/blowdown-evaporator-ultravap-levante/
https://clinlabint.com/wp-content/uploads/sites/2/2021/04/Porvair566.jpg 1618 1316 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2021-04-06 10:27:312021-04-06 10:27:31Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator
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