Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis
Thermo Fisher Scientific unveils HPLC Ion Exchange Columns for Protein Charge Variant and AAV Separation Analysis
Thermo Fisher Scientific is providing biopharmaceutical research laboratories with a new line of ion exchange columns that deliver superior reproducibility, sensitivity and durability for charge-based analysis of therapeutic proteins and separation of full vs. empty adeno-associated virus (AAV) capsids used for gene therapy.
The Thermo Scientific ProPac 3R HPLC column portfolio leverages a novel monodisperse particle platform and state-of-the-art separation power to deliver outstanding lot-to-lot reproducibility and consistent results over the lifecycle of a drug, from research and development to commercialization. The new 3 µm particle size enables a new level of performance with ultra-high resolution of charge variants, improved peak resolution and faster run times. The portfolio supports strong anionexchange (SAX) and strong cation-exchange (SCX) column chemistries, each with two column lengths (50mm and 100mm) and
two inner diameters (2mm and 4mm).
Key applications, include: Biopharmaceutical laboratories performing charge variant analysis of therapeutic proteins, including monoclonal antibodies, and separation of full versus empty AAV capsids used for gene therapy.
The main features include:
• Compatible with the mobile phases and organic solvents used in biopharmaceutical applications
• Designed with bio-inert materials to reduce secondary interactions
• Improved peak-to-valley resolution of charge variants to increase certainty of quantification of critical quality attributes
• Confidence in the detection and identification of new acidic or basic variants during late-stage development
• High sample-loading capacity
• Analytical flexibility for excellent sensitivity and performance under a broad range of pH, temperature and mobile phase compositions as well as MS capabilities
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