Los Angeles-based EntroGen, Inc. has launched a PCR-based Microsatellite Instability (MSI) Detection Kit designed for research use, targeting laboratories equipped with standard qPCR instrumentation. The assay offers a streamlined approach to detecting MSI, a molecular signature present in a subset of colorectal cancers.

High-resolution melting workflow simplifies analysis The kit employs high-resolution melting (HRM) technology to identify microsatellite instability patterns. EntroGen provides complimentary data analysis software to facilitate interpretation of HRM results, enabling visualisation and assessment of MSI status directly within qPCR-equipped facilities.

Established biomarkers ensure detection sensitivity

The assay targets five well-characterised microsatellite markers: BAT-25, BAT-26, NR-21, NR-27, and MONO-27. These loci were selected for their established correlation with microsatellite instability in colorectal cancer, supporting reproducible detection outcomes.

“Many MSI testing methods on the market have their own unique challenges,” said Matthew Minkovsky, CEO of EntroGen. “With our kit, we’ve simplified the testing process by removing unnecessary technical barriers and offering a solution that’s both high-performing and easy to adopt on leading qPCR platforms.”

The MSI Detection Kit is available for research use only and can be purchased directly from EntroGen or through authorised distributors.

For more information, visit: www.entrogen.com

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