β-Hydroxybutyrate reagent
A new reagent for measuring β-Hydroxybutyrate in serum and plasma is now available from BioSystems.β-Hydroxybutyrate (BHB) is produced along with acetoacetate and acetone during ketosis in carbohydrate deprivation (starvation, digestive disturbances, frequent vomiting), decreased carbohydrate utilization (diabetes mellitus), glycogen storage diseases, and alkalosis. Acetone usually accounts for only 2% of the total ketone bodies and it is excreted in the urine or exhaled. Acetoacetate normally accounts for about 20% and could be spontaneously converted to acetone and CO2 or metabolized by the liver into BHB, which accounts for the majority (78%), so it is the best marker for the diagnosis of hyper- or hypo- ketotic state or monitoring therapy for diabetic ketoacidosis. For performing the calibration, it is recommended to use the Biochemistry Calibrator or the Biochemistry Calibrator (Human) and the Biochemistry Control Serum levels I and II or Biochemistry Control Serum (Human) levels I and II to verify the measurement procedures.
Supplier: BioSystems
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