Serum uromodulin ELISA
Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in urine under physiological conditions. It is exclusively produced in the kidney and secreted into the urine via proteolytic cleavage. It has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. Genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease (CKD) and hypertension, and suggested that urine uromodulin could represent a useful biomarker for the development of CKD. Recently, serum uromodulin determination exhibited characteristics superior to its measurement in the urine. Low serum uromodulin concentrations were associated with ANCA vasculitis, SLE, polycystic kidney disease, IgA nephropathy and preeclampsia. Using the cut-off 125.4 ng/mL uromodulin had a unique clinical sensitivity of 92.1% and specificity of 100.0% showing that it might be used as a screening nephropathy marker. BioVendor’s patent for the use of the serum uromodulin determination for the diagnosis of nephropathy is pending.
Supplier: BioVendor Research and Diagnostic Products
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