A new addition to the Stat Profile line of blood gas critical care analysers, Stat Profile Prime Plus, has gained CE mark certification and is now available in all CE-regulated countries. Prime Plus features maintenance-free sensor technology to provide 22 essential critical care tests including blood gases, electrolytes, metabolites, hematology, and co-oximetry. Prime Plus also features new and patented, non-lysing whole blood co-oximetry technology, along with automated quality control (QC), powerful data management, bidirectional connectivity, and extensive cybersecurity protection. Prime Plus incorporates Nova’s innovative, maintenance-free sensor technology with individual MicroSensor cards, calibrator cartridges, and quality control cartridges. This design eliminates sensor and co-oximeter maintenance, improves analyser uptime, and reduces testing costs. The MicroSensor Card provides 22 whole blood assays including co-oximetry and new critical care assays for urea, creatinine, and ionized magnesium. Prime Plus provides a complete co-oximetry panel without chemically or mechanically lysing the blood, which eliminates corrosive lysing reagents and mechanical complexity and improves instrument reliability and reduces costs. Prime Plus delivers a comprehensive critical care panel in about one minute from 135 microliters of whole blood. Tests include pH, PCO2, PO2, SO2%, Na, K, Cl, iCa, iMg, TCO2, glucose, lactate, urea, creatinine, Hct, Hb, O2Hb, COHb, MetHb, HHb, HbF, and tBil. A special safety sample port allows for easy docking and hands-free sampling, and the Clot Bloc sample flow path protects sensors from blood clot blockages and related downtime. Prime Plus provides total quality monitoring with automated QC that verifies analyser accuracy and precision on assayed liquid controls, and supplemental quality monitoring that electronically monitors and verifies correct performance of all analytical components for each analysis and calibration. It also features a powerful data management system and bidirectional connectivity, remote analyser review and control of connected Prime Plus analysers, and the most comprehensive cybersecurity features to protect patient health information and prevent viruses.