The National Institutes of Health, U.S. Food and Drug Administration, 10 pharmaceutical companies and five non-profit organizations have partnered to accelerate development of gene therapies for the 30 million Americans who suffer from a rare disease.
A study out of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University has resulted in the discovery of a promising new antimalarial compound.
BBMRI, EATRIS and ECRIN, the medical European research infrastructures, supported by the European Strategy Forum on Research Infrastructures (ESFRI), have joined forces by forming the European Alliance of Medical Research Infrastructures (EU-AMRI). EU-AMRI aims to facilitate the effective and efficient use of scientific services, expertise and tools by academia and industry for the seamless translation […]
Professor Braeckmans from Ghent University focused the last ten years on a method for safe engineering of therapeutic cells with photothermal nanofibers. The study published in Nature Nanotechnology gives insight in how these biocompatible photothermal nanofibers were developed, and how, upon laser irradiation, cells that come in contact with those nanofibers become permeabilized and can […]
Inhibitors that block the activity of the proteasome are already applied to treat various types of cancer. However, existing drugs affect proteasomes in all the cells of our body, which can lead to unwanted side-effects in healthy cells.
The scientists found that AKIRIN2 was consistently associated with the proteasome and not only required for the regulation of MYC, but of many more short-lived proteins. To their surprise, they found that AKIRIN2 only affected nuclear proteins, which accumulated freely in its absence. Thus, they hypothesised that AKIRIN2 might help the proteasome to enter the […]
Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a CRISPR-Cas9 screening assay that allows to systematically pinpoint regulators of any gene of interest, including cancer-related genes. Using this approach, they discovered how cells transport their clean-up machinery, the proteasome, into the nucleus to maintain protein balance and get rid of […]
CN Bio, a leading organ-on-a-chip company that designs and manufactures single- and multi-organ microphysiological systems (MPS), has launched its Oncology Service in response to the global need to improve cancer drug discovery approval rates.
Evonetix, the synthetic biology company developing a desktop platform for scalable, high-fidelity and rapid gene synthesis, has been granted patent GB 2576304 for its novel method for DNA data storage and retrieval.
FUJIFILM Irvine Scientific, has completed construction and started the commissioning phase of its new manufacturing facility in Tilburg, the Netherlands. The commissioning milestone marks the beginning of validating the facility and equipment in anticipation of full operations starting in late 2021. The new facility will join manufacturing locations in the U.S. and Japan to increase […]
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