Digital pathology adoption is expanding beyond routine histology into more complex cytology and histopathology workflows, with growing demand from laboratories for improved image clarity, increased workflow integration and better system inter-operability. Hologic is addressing this demand with a unified Digital Pathology Solution for digitization and review of cytology and histology in one system.

The need for clarity

Consistently clear digital images are essential for confident interpretation, particularly when reviewing complex cytology and histology specimens [1]. Conventional whole-slide imaging generally involves capturing a single focal plane, which may suit thin, uniform sections, but can limit clarity with varying tissue thickness or 3D structures. Volumetric imaging enables effective digital scanning for both cytology and histology, with 14 focal planes captured in a single pass, and merged to a high clarity composite image (Fig. 1) [2,3].

A unified approach to digital pathology

Hologic has longstanding expertise in digital cytology, and is extending this experience into histology through the Genius™ Digital Diagnostics System, which incorporates volumetric imaging as a core scanning capability [3]. The Genius Digital Diagnostics System quickly converts whole slide histology into high resolution images ready for review [2,3]. Laboratories can image, store and review cytology and histology specimens on a digital system that consolidates workflows, costs and footprint [2,3].

“The ability to image and review more types of samples within a single system will help us to think beyond traditional boundaries and provide greater precision and efficiency in our work.”
– Professor Paul van Diest, University Medical Centre Utrecht, The Netherlands

Fig. 1. Volumetric imaging allows better analysis of tissue
(a) Tissue with folds and wrinkles.
(b) Tissue that is fatty, thick or fragmented.
(c) The system enables review of cytology and histopathology specimens – both gynecological (GYN) and non-gynecological (NGYN) – in one platform.

 References
1. Ahuja S, Zaheer S. Advancements in pathology: digital transformation, precision medicine, and beyond. J Pathol Inform. 2024;16:100408. PMID: 40094037 (https://doi.org/10.1016/j.jpi.2024.100408).
2. Genius™ Digital Diagnostics – Histology [website]. Hologic® UK 2026 (https://www.hologic.co.uk/en-gb/products/genius-digital-diagnostics-histology).
3. Genius™ Digital Diagnostics System Whole Slide Imaging: instructions for use [PDF]. Hologic Inc. 2025 (AW-32577-002_Rev 001).

Hologic BV
1930 Zaventem
Belgium

To learn more about Hologic’s range of digital pathology solutions for histology, visit: https://www.hologic.co.uk/en-gb/products/genius-digital-diagnostics-histology

*Product availability, slide types and indications for use may vary by country. Please refer to local regulatory labelling and instructions for use.