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Drug testing, fingerprints and the future
Standard drug testing is regularly carried out using urine, blood or oral fluid. However, fingerprints present a good alternative, as the sample collection is non-invasive, rapid and safe. Herein, we describe the application of two different testing methods for the detection of cocaine in fingerprint samples. by Dr Catia Costa, Dr Mahado Ismail and Dr […]
Biomarkers for improving the diagnosis of acute interstitial nephritis
Acute interstitial nephritis (AIN) may be the cause of more than 15 % of instances of acute loss of kidney function. Diagnosed early, it can often be successfully treated; however, lack of obvious symptoms means it can be easily missed. Left untreated, AIN can progress to chronic kidney disease. Currently, clinical diagnosis is confirmed by […]
MicroRNAs show potential as molecular biomarkers for graft-versus-host disease
Graft-versus-host disease is a serious complication following hematopoietic stem cell transplantation (HSCT), with a high mortality rate. A clearer understanding of the molecular pathogenesis may allow robust biomarker identification and improved therapeutic options. MicroRNAs (miRNAs) are short non-coding regulatory RNAs that are expressed in both tissue and body fluids, and show great potential as clinically […]
Molecular Diagnostics Literature Review
Genome-wide analysis of circulating cell-free DNA copy number detects active melanoma and predicts survivalSilva S, Danson S, Teare D, Taylor F, Bradford J, et al. Clin Chem 2018; 64(9): 1338–1346. BACKGROUND: A substantial number of melanoma patients develop local or metastatic recurrence, and early detection of these is vital to maximize benefit from new therapies […]
Colistin resistance detection in Acinetobacter baumannii by mass spectrometry of microbial lipids
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections with colistin can result in emergence of colistin-resistant strains. This occurs via modifications of the phosphate moieties of lipopolysaccharide-derived lipid A, which are readily identified by mass spectrometry (MS). In this article, we describe colistin susceptibility determinations by […]