Flow cytometry is one of many analytical techniques used in clinical development to help discover new biomarkers and aid in development of new therapies. This article highlights how automated gating can expedite data processing and management, leading to improved productivity and insights in flow cytometry analysis for clinical research.
Optical fibres have revolutionized clinical practice in the form of the optical endoscope, and are now providing the framework for an entirely new endoscopic paradigm: all-optical ultrasound. Here we describe a phonon probe, which offers a route towards cellular resolution acoustic imaging – while also offering new capabilities such as label-free contrast and parallel spectroscopy […]
Although we have a reasonable understanding of a number of mechanisms of epigenetic regulation, we are still have a lot more to learn about the impact and influence of epigenetic regulation, particularly in relation to disease. CLI caught up with Professor Michael Skinner (Center for Reproductive Biology, Washington State University, USA) to find out more […]
The development of molecular biology has driven a revolution in our understanding of disease at the molecular level, greatly improving diagnosis, prognosis and therapeutic decision-making. The study of both data and physical specimens deposited in biobanks is crucial for this. However, the vast majority of biobanks are based in Europe and North America, and the […]
Prostate cancer is an extremely complex and heterogenous disease. A significant problem in the clinical management of PCa is being able to accurately stratify patients based on their risk for aggressive disease. Traditional biomarkers and clinical methods for personalized treatment are insufficient. Appropriate stratification of patients based on their risk for aggressive disease is required […]
The majority of magnesium in the body is located in bone and muscle; however, the small extracellular proportion of ionized magnesium plays an important role in a number of physiologic processes. Generally, when assessing magnesium concentration, total magnesium is measured. This article discusses the importance of ionized magnesium and why we should be directly measuring […]
Despite the progress that has been achieved in Lyme disease (LD) diagnostic development in recent years, lack of early and effective diagnosis of LD remains a major cause of misdiagnosis and long-term patient suffering. We invented a novel way of detecting LD-causing bacteria. The new technology could potentially transform LD diagnostics through the innovative use […]
When specimens are analysed in the clinical laboratory, it is crucial that the results that are reported back to the clinician are accurate. If not, at best, results would not be comparable from the same laboratory on different days or between different laboratories at all. At worst, disease could remain undiagnosed or over-diagnosed with the […]
by Dr T. Truong, Dr J. Dien Bard and Dr R. Yee Nasopharyngeal swabs are recommended as the preferred sample type for detecting infection with SARS-CoV-2. However, there has been considerable interest in other collection methods, especially if they can circumvent supply shortages and the requirement for trained healthcare workers to administer them. Here we […]
by Dr O. Robertson-Gray and Dr W. Fuller Cardiovascular disease (CVD) is the umbrella term for conditions affecting the heart or blood vessels and remains the leading cause of death worldwide. New therapeutic strategies to aid in the prevention and treatment of CVD are therefore necessary. This article discusses the potential for S-acylation, a post-translational […]
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