by Dr Robert Reed and Dr Soheyl Tadjiki Viruses are increasingly used as gene therapy vectors in modern medicine. In order to minimize unwanted side effects such as immunogenicity, accurate determination of viral aggregation status is important. Field-flow fractionation is emerging as one of the most robust techniques for the separation and size measurement of […]
by Jean Deenmamode The concept of testing breath, blood or urine for alcohol is familiar to the general public, and blood alcohol testing is widely used across a range of industries, from aviation to driver licensing. But is a snapshot alcohol measurement really the best approach to ensuring longterm safety in these industries, or identifying […]
by Dr Nicolas Gerst Pipettes are important tools widely used in the lab. They are usually chosen and purchased carefully with the goal of receiving the best performance for a given price. Pipette tips are consumables; therefore, price can be an important factor, sometimes at the detriment of quality and performance. We found that tips […]
Histopathology is a crucial stage in the diagnosis of many diseases, particularly cancer staging and therapy management. Current challenges facing pathology are a shortage of pathologists and an increasing workload resulting from expanded screening programmes, increased test complexity and an increasing elderly population. Leeds Teaching Hospitals NHS Trust, UK, has a fully subspecialized diagnostic histopathology […]
by Dr Mustafa Yousif, Dr David S. McClintock and Dr Keluo Yao Artificial intelligence (AI) has the potential to optimize anatomic pathology (AP) laboratory efficiency, enhance pathologists’ diagnostic skills, elevate case reimbursement and, ultimately, improve patient care. To realize this potential, AP laboratories must overcome the barriers to adopting digital pathology (DP) while DP vendors […]
by Dr Ruth Ayling Calprotectin is a protein derived from neutrophils and its presence in feces can be used as a surrogate marker of gastrointestinal inflammation. Measurement is useful to differentiate inflammatory bowel disorder (IBD) from functional bowel disease, which has similar clinical features but different etiology, and to manage patients with established IBD.
by Dr Christina C. Pierre and Dr Lindsay Bazydlo Heparin-induced thrombocytopenia (HIT) is a hypercoagulable disorder that is mediated by antibodies against heparin complexed to platelet factor 4. HIT antibodies activate platelets, which generate a self-propagating, pro-coagulant state. A subset of patients with HIT develop thrombosis that can be limb- and/or life-threatening. This review provides […]
by Dr Jacqueline Gosink Tumour necrosis factor (TNF) inhibitors are increasingly used to treat chronic inflammatory bowel diseases, rheumatic diseases and psoriasis. Continuous drug level monitoring and administration interval adjustment accompanying the treatment with TNF inhibitors is the key to successful, individualized and targeted patient care. Concentrations of the TNF inhibitors adalimumab or infliximab can […]
In August 2020 new guidance was issued by the National Institut e for Health and Care Excellence on the use of high-sensitivity troponin tests for the early rule-out of non-ST-elevation myocardial infarction (NSTEMI). CLI caught up with Heather Read-Harper from Beckman Coulter to find out more about the use of cardiac troponin biomarkers in the […]
One of the conundrums presented by COVID-19 is that it is not uncommon for patients to present with remarkably low oxygen saturation levels but with very little breathlessness. Additionally, it has been noted that there is an additional risk of stroke in COVID-19 patients (and COVID-19-recovered patients) and that they seem to have what is being referred to as ‘sticky blood’. A recent paper by Professor Yost (Department of Pediatrics, University of Utah School of Medicine, UT, USA) and colleagues ‘Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome’ discusses the role that neutrophil extracellular traps (NETs) can play in the development of these symptoms and prothrombotic disease outcomes. CLI was very fortunate to catch up with Professor Yost to learn more about NETs and their effects in COVID-19 and other conditions.
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