For the measurement of fibrinogen concentration in plasma, Fibrinogen by BioSystems is a turbidimetry liquid bireagent method which is calibrated with a multipoint curve (lyophilized standard) and controlled with a lyophilized control plasma. Fibrinogen is a protein that is essential for blood clot formation. It is produced by the liver and released into the circulation as needed along with several other clotting factors. The concentrations of fibrinogen are increased in case of diabetes, obesity and inflammatory syndromes and are decreased in case of disseminated intravascular coagulation (DIC), fibrinolysis and genetic deficiency. In addition, elevated concentrations of fibrinogen can be involved in the pathogenicity of different cardiovascular thrombotic events. In recent years, a large number of prospective studies have shown that the fibrinogen concentration is a predictor of a variety of cardiovascular events, including stroke, myocardial infarction, leg ischemia (in arterial disease) and postsurgical arterial re-occlusion.