High-sensitive cardiac troponin T: the issue of hemolysis interference

Cardiac troponin is the gold standard biomarker for diagnosis of acute myocardial infarction. The introduction of high-sensitive cardiac troponin assays has further strengthened its power in early rule-in/rule-out testing. However, since these assays are susceptible to hemolysis interference, sample rejection due to hemolysis (commonly seen in samples from the Emergency Department) remains one of the biggest challenges.