C304 BioVendor

Human MxA Protein ELISA

Designed for the measurement of MxA protein in human whole blood, an innovative ELISA based on the use of patented monoclonal antibodies and a special buffer to extract the cytoplasmic MxA protein is suitable for the monitoring of IFN-β therapy in multiple sclerosis patients and for viral infection recognition. Human Myxovirus protein A is induced exclusively by IFN-α and IFN-β. Since direct measurement of the IFN levels in plasma is difficult, MxA may be useful as a marker distinguishing viral disease from bacterial infection or from acute graft-versus-host disease after allogenic stem cell transplantation. Neutralizing antibodies may develop during the IFN-β therapy of multiple sclerosis and lead to loss of drug bioactivity. The IFN-β-inducible MxA protein is an ideal marker of IFN-β bioavailability, capable of discriminating between biologically responsive and non-responsive patients. The BioVendor assay meets all the requirements for routine clinical use in manual mode as well as on open ELISA robotic systems.

Supplier: BioVendor Research and Diagnostic Products

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