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Human neudesin ELISA kit

A human neudesin ELISA has been developed and validated by BioVendor to measure circulating neudesin levels. Neudesin plays roles in neural functions, energy metabolism, and tumourigenesis and is considered to be a novel target for obesity and cancer treatments. Human neudesin (neuron-derived neurotrophic factor) is a unique secreted protein with a conserved cytochrome 5-like heme/steroid-binding domain belonging to the MAPR (membrane- associated progesterone receptor) family with multiple roles. Neudesin is expressed in the mouse embryonic cerebral cortex and the neural precursor cells where it significantly promotes neural cell differentiation and also transiently promotes neural cell proliferation during the early stages of development. Neudesin is also abundantly expressed in white adipose tissue of adult mice and also in hypothalamic nuclei that regulate food intake. The appetite-suppressing effect of neudesin was abrogated in obese mice fed a high-fat diet, demonstrating a diet-dependent modulation of neudesin function. Neudesin knockout mice were resistant to high-fat diet (HFD)-induced obesity due to elevated systemic sympathetic activity, heat production, and adipocytic lipolysis. Finally, neudesin is over-expressed in multiple human cancers including carcinoma of the breast, colon, lung, uterine cervix, skin and malignant lymphoma. The tumourigenesis mechanism involving neudesin might be mediated by activation via the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways.

Supplier: BioVendor Research and Diagnostic Products

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