Non-invasive diagnosis of diseases such as osteoporosis and Alzheimer’s

Scientists from the University of Granada have developed a new fluorescent dye capable of detecting, in a single test lasting 20 minutes, the presence of phosphate and biothiol inside living cells. This scientific breakthrough could contribute significantly to the early diagnosis of diseases such as osteoporosis, Alzheimer’s, type 2 diabetes, and prostate cancer, since abnormal levels of both substances are associated with these diseases.

The main author behind the study, Luis Crovetto González, explains: “We have successfully managed to create, for the first time, a dual function dye capable of detecting both substances in the same test. Until now, this procedure has been conducted using two separate fluorescent dyes and/or two separate tests.”

In 2014, the same research group patented a new non-invasive method that allows for the measurement, in real-time, of concentration levels of phosphate ions inside living cells. This new dye that they have developed is, in effect, the continuation of this previous research and subsequent patent.

The importance of being able to measure phosphate ions stems precisely from the fact that these measurements can be employed to assess the bioavailability of drugs used to treat certain diseases, among others, osteoporosis.

At present, the only available method for calculating the concentration levels of phosphates found inside the osteoblasts (the precursor cells of bone) is invasive, employing radioactive phosphorous, the use of which carries serious risks. University of Granada