Bio-Rad Laboratories has introduced four inhibitory antibodies that are highly specific to pertuzumab (Perjeta). These ready-made antibodies inhibit the binding of the drug to its target, human epidermal growth factor 2 (HER2), enabling researchers to develop highly selective and sensitive assays for bioanalysis and drug monitoring of pertuzumab and its biosimilars.
Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation. The new range of anti-pertuzumab antibodies includes monovalent Fab format antibodies suitable for the development of a pharmacokinetic bridging ELISA to measure free drug, as well as fully human IgG1 antibodies with varying levels of affinity, which can be used as a surrogate positive control or reference standard in an anti-drug antibody assay.
Recombinant, monoclonal anti-idiotypic antibodies
“We’re continuously introducing new ranges of recombinant, monoclonal anti-idiotypic antibodies to support researchers in developing robust methods that deliver reproducible and translatable results,” said Amanda Turner, Bio-Rad Product Manager, Life Science Group. “These sequence-defined reagents are well-characterized and non-animal-derived to ensure batch-to batch consistency and help reduce the use of animals in scientific research,” she said.
The antibodies are generated using the Human Combinatorial Antibody Libraries (HuCAL) and CysDisplay, a proprietary method of phage display, along with guided selection methods to obtain highly targeted reagents. The recombinant production method ensures a consistent and secure supply.
The anti-pertuzumab antibodies are approved for in vitro research purposes and for commercial services providing in vitro testing to support preclinical and clinical drug development.
Bio-Rad launches anti-pertuzumab antibodies
, /in Product News /by panglobalBio-Rad Laboratories has introduced four inhibitory antibodies that are highly specific to pertuzumab (Perjeta). These ready-made antibodies inhibit the binding of the drug to its target, human epidermal growth factor 2 (HER2), enabling researchers to develop highly selective and sensitive assays for bioanalysis and drug monitoring of pertuzumab and its biosimilars.
Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation. The new range of anti-pertuzumab antibodies includes monovalent Fab format antibodies suitable for the development of a pharmacokinetic bridging ELISA to measure free drug, as well as fully human IgG1 antibodies with varying levels of affinity, which can be used as a surrogate positive control or reference standard in an anti-drug antibody assay.
Recombinant, monoclonal anti-idiotypic antibodies
“We’re continuously introducing new ranges of recombinant, monoclonal anti-idiotypic antibodies to support researchers in developing robust methods that deliver reproducible and translatable results,” said Amanda Turner, Bio-Rad Product Manager, Life Science Group. “These sequence-defined reagents are well-characterized and non-animal-derived to ensure batch-to batch consistency and help reduce the use of animals in scientific research,” she said.
The antibodies are generated using the Human Combinatorial Antibody Libraries (HuCAL) and CysDisplay, a proprietary method of phage display, along with guided selection methods to obtain highly targeted reagents. The recombinant production method ensures a consistent and secure supply.
The anti-pertuzumab antibodies are approved for in vitro research purposes and for commercial services providing in vitro testing to support preclinical and clinical drug development.
Ziath introduces high resolution single tube reader
, /in Product News /by panglobalZiath has released their new ‘Uno single tube reader’ – a powerful device packed with features to make sample management work with 2D barcoded tubes easier and faster.
Measuring 66 x 53.5 x 51.5 millimetres – the rugged new tube reader features a high-resolution camera capable of reading 2D barcodes from any currently available tube on the market including 384-well tubes. Simply hold the tube to the scanner window and the code is instantly displayed.
Affordably priced, the Uno single tube reader also has an optional capability to read Brooks Acoustix tubes.
The reader can be supplied with or without optional cryoprotection to enable trouble-free scanning of tubes taken straight from cold storage.
The USB 3 device acts as a Microsoft Keyboard Wedge and inserts the barcode into any open programme on the desktop. The enhanced drivers allow the Uno to be ready to read immediately with no lag time and allows adjustment of the camera for changes in contrast between different manufacturers’ tubes.
Reliable Track & Trace Scanner for COVID-19 Samples
, /in Product News /by panglobalSince the start of the COVID-19 pandemic, nations worldwide have vastly expanded their testing capacity by establishing huge networks of diagnostic testing facilities, including the public and private sector, and not-for-profit organizations.
Serum Amyloid A (SAA) nephelometric and turbidimetric assays
, /in Product News /by panglobalTRIMERO Diagnostics offers assays for testing Serum Amyloid A (SAA) on Beckman Coulter’s IMMAGE® Immunochemical Systems and Clinical Chemistry Analyzers.
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Gastrointestinal Disorders: Literature Review
, /in Featured Articles /by panglobalThiopurine pharmacogenomics and pregnancy in inflammatory bowel disease Andoh A, Kawahara M, Imai T, et al. J Gastroenterol 2021; 56(10): 881–890 The thiopurine drugs azathioprine and 6-mercaptopurine are widely used for the maintenance of clinical remission in steroid-dependent inflammatory bowel disease (IBD). Thiopurines are recommended to be continued throughout pregnancy in IBD patients, but conclusive […]