The first analyzer in the world to use an excimer lamp /
Minimum footprint, highly sensitive, environment-friendly /
Targeting precision manufacturing, pharmaceuticals, semiconductors
Shimadzu, one of the world leaders in analytical instrumentation, has released the TOC-1000e, the first analyzer in the eTOC series of on-line TOC analyzers designed for pure water applications. The eTOC series’ main focus is on miniaturization, high sensitivity and a mercury-free oxidation technique. The pioneering TOC-1000e system has the world’s smallest and lightest cabinet and provides high-sensitivity detection, making it ideal for fields requiring high-purity water applications. This covers manufacturing, including pharmaceuticals, semiconductors, food & beverages, chemistry and precision equipment.
Total organic carbon (TOC) analyzers are used to rapidly quantify organic substances in water, allowing decisive process intervention. Among many fields of application, they are used mainly for water quality control and environmental investigations. Shimadzu’s world-leading TOC analyzers are well-suited to laboratory and on-line analysis of environmental and waste water. The eTOC series will be Shimadzu’s first on-line TOC analyzer designed especially for pure water measurements.
Minimum footprint, highly sensitive, environmental-friendly
The TOC-1000e provides enhanced robustness in the ultra-low measurement range. With its small footprint of less than A4 size, it can be installed flexibly – either as table-top, wall-mounted or pole-mounted.
Conventional TOC analyzers for pure water utilize mercury UV lamps as the light source within the instrument. To provide a more environmental-friendly alternative, the eTOC series is the first analyzer in the world to use an excimer (short for ‘excited dimer’) lamp rather than a mercury lamp.
The “Active-Path” flow line design maximizes lamp power by integrating the sample flow channel and the light source. This minimizes sample residue in the flow channel and eliminates interfering air layers, so high sensitivity is maintained over long-term use. This new design also contributes to making the eTOC series instruments small and light.
Features
The TOC-1000e combines high-sensitivity and easy-to-use features benefiting effortless data management, efficiency and handling.
Some of the features include:
- State-of-the-art oxidation technology in the smallest casing
The TOC-1000e provides high sensitivity with a detection limit of 0.1 μg/L. It is housed in the world’s smallest and lightest cabinet and equipped with the industry’s largest color touch panel, providing exceptional visibility, simplifying operation and allowing effortless management of compliance relevant data. In addition, the novel fluid system minimizes sample residue in the flow channel, ensuring that high sensitivity is maintained.
- Easy-to-use and to maintain design improves efficiency
The eTOC series has a simple design, and parts typically do not need to be replaced for one year; this increases efficiency by reducing maintenance and re-validation effort. Consumable parts (excimer lamp and pump head) can be removed and installed without tools. Using an optional sampler, the analyzer can be calibrated or validated (confirmation of manufacturing process validity) at the operating site. Certified standard solutions particularly for this series are available; they save customers the time and expense of purchasing and preparing items from a reagent manufacturer, and reduce mistakes caused by human error. In addition to analog interface and digital I/O, measurement data can be output to a printer or USB flash drive, or browsed and acquired via a built-in web server.
- Support for Regulatory Compliance
eTOC’s highly sensitive UV oxidation-conductivity method for ultra-pure water monitoring is compliant with regulatory requirements such as the United States (USP) and the European Pharmacopeia (EP). Inbuilt security functions including user authentication and audit trail, support compliance with regulations such as FDA 21 CFR Part 11. The LabSolutions software platform provides integrated management of the measurement data together with data and electronic signature functions (ER/ES) from laboratory TOC analyzers and other analytical instruments.
For more information, visit: https://www.shimadzu.eu/toc-analysis/etocseries
Paradigm4 unveils analytical development data management tool to unlock Allotrope data format ‘treasure trove’
, /in E-News /by panglobalParadigm4 has unveiled its scalable solution for efficiently working with the Allotrope Data Format (ADF).
AMSBIO introduces range of cytosections for antibody screening, immunohistochemistry protocol development
, /in E-News /by AMS Biotechnology (UK) LTDAMSBIO has launched a comprehensive range of cytosections that offer a verified, reproducible and renewable source of positive / negative controls where the expression of the target biomarker is confirmed for accuracy and specificity by an immunoassay.
DiaSys launches SARS-CoV-2 UTAB FS for reliable monitoring of total antibodies for SARS-CoV-2
, /in Product News /by DiaSys Diagnostic Systems GmbHQuantitative assessment of antibodies in Covid-19 is becoming increasingly important. It provides information on the actual spread of infection in the population and enables characterization of a vaccine-induced immune response.
Book now for UKMedLab21 – integrating FOCUS & FiLM
, /in Events /by panglobalCB is delighted to welcome you to register for its first online national congress UKMedLab21. The meeting, which integrates the meetings formerly known as FOCUS and Frontiers in Laboratory Medicine (FiLM) will offer delegates the opportunity to hear from leaders in clinical science, laboratory management and education about development in policy, practice and management.
UKMedLab21 is packed with multiple sessions in two key streams: Leadership & Management and Science & Education.
The event will help laboratory professionals at all levels to regain ground on essential CPD activity that may have been lost in 2020 during the pandemic. We’ll also be featuring a Training Day on 14th June, virtual poster sessions and awards and an industry Expo in partnership with the British Invitro Diagnostics Association (BIVDA).
Flexible ticket types allow you to build a programme tailored to your interests, availability and budget. Workshops will include moderated Q&A opportunities with speakers and presenters.
Evaluation of Recovery of Basic Analytes with Microlute® CP 30 mg Mixed-Mode Strong Cation Exchange (SCX) SPE by HPLC-MS
Laboratory, /in White Papers /by panglobalBackground Sample preparation is important in any type of chromatography analysis. While it can add on extra time, the process of cleaning up samples before injection onto a system results in a range of benefits to the analyst – better recoveries, more reproducible analysis, less downtime of instruments, reduction of troubleshooting, as well as less […]
Bio-Rad launches its Reliance SARS-CoV-2 RT-PCR assay kit in Europe
, /in Product News /by panglobalBio-Rad Laboratories has launched its Reliance SARS-CoV-2 RT-PCR Kit (IVD) for European markets after having met the CE-IVD mark requirements. The Reliance SARS-CoV-2 RT-PCR Kit is a real-time reverse-transcription PCR (RT-PCR) test that can detect nucleic acid in SARS-CoV-2, the virus associated with COVID-19 disease. A version of the assay kit is also available in the United States under an U.S. FDA emergency use authorization (EUA).
The Reliance SARS-CoV-2 RT-PCR Kit (IVD) is designed for clinical diagnostic labs that conduct COVID-19 testing. The assay kit offers the qualitative detection of two separate target regions in the nucleocapsid gene (N1 and N2 regions) of SARS-CoV-2 in nasopharyngeal swab specimens from individuals suspected of being infected by COVID-19.
Because the test are designed to target the nucleocapsid gene, the assay’s performance is not affected by known coronavirus variants as determined by in-silico analysis. The assay kit contains Bio-Rad’s standard and negative molecular controls as well as assay reagents. It is validated to run on Bio-Rad’s CFX96 Dx RT-PCR system, as well as RT-PCR systems from other manufacturers.
“We are excited about the European launch of our SARS-CoV-2 RT-PCR Kit (IVD), a reliable, sensitive, and accurate solution for COVID-19 testing,” said Steven Blakely, Bio-Rad Global Director of Marketing, Life Science Group, Gene Expression. “Testing laboratories worldwide use Bio-Rad’s RT-PCR systems for the detection of SARS-CoV-2. The assay kit is the latest addition to our COVID-19 offering of research and testing products, reflecting our ongoing commitment to helping in the fight against COVID-19,” he said.
INTEGRA’s serological pipettor speeds up cell culture workflows
Laboratory, /in Product News /by panglobalAnion dysregulation is seen in numerous diseases, from cystic fibrosis and chronic pain, to autism and cancer. Researchers at the University of Dallas are investigating anion transport in vivo, developing novel tools to help analyse the effects of both normal and aberrant anion regulation at the molecular level, and are using INTEGRA’s PIPETBOY acu 2 to streamline their cell culture workflows.
Whitney Ong, a joint chemistry graduate student in the Dodani and Smaldone labs at the university, explained: “My research focuses on the development of supramolecular-based sensors for anions, particularly for chloride. The reason we are especially interested in chloride is that it is the most abundant anion in the human body – serving all sorts of functions – and its dysregulation is implicated in diseases such as cystic fibrosis. We’re hoping that our chloride sensing platform could help in its detection, as well as in the diagnosis of a number of other diseases.”
Ong added: “We have three PIPETBOY pipette controllers and use them regularly for a variety of tasks during our cell culture set-up, for instance to make up large volumes of cell culture media, aliquoting and dispensing reagents such as media or antibiotics, resuspensions, as well as to mix different solutions. If we are working with volumes of liquids above 2 ml, we will always use the PIPETBOY; it’s much easier, safer and more efficient that pouring liquids between glass measuring cylinders, where there is a higher risk of spillages or not pouring out the desired volume. They fit into our workflows perfectly – everyone in the lab loves them.”
For more information visit: www.integra-biosciences.com
Shimadzu releases online TOC analyzer designed for pure water applications
Laboratory, /in Product News /by panglobalThe first analyzer in the world to use an excimer lamp /
Minimum footprint, highly sensitive, environment-friendly /
Targeting precision manufacturing, pharmaceuticals, semiconductors
Shimadzu, one of the world leaders in analytical instrumentation, has released the TOC-1000e, the first analyzer in the eTOC series of on-line TOC analyzers designed for pure water applications. The eTOC series’ main focus is on miniaturization, high sensitivity and a mercury-free oxidation technique. The pioneering TOC-1000e system has the world’s smallest and lightest cabinet and provides high-sensitivity detection, making it ideal for fields requiring high-purity water applications. This covers manufacturing, including pharmaceuticals, semiconductors, food & beverages, chemistry and precision equipment.
Total organic carbon (TOC) analyzers are used to rapidly quantify organic substances in water, allowing decisive process intervention. Among many fields of application, they are used mainly for water quality control and environmental investigations. Shimadzu’s world-leading TOC analyzers are well-suited to laboratory and on-line analysis of environmental and waste water. The eTOC series will be Shimadzu’s first on-line TOC analyzer designed especially for pure water measurements.
Minimum footprint, highly sensitive, environmental-friendly
The TOC-1000e provides enhanced robustness in the ultra-low measurement range. With its small footprint of less than A4 size, it can be installed flexibly – either as table-top, wall-mounted or pole-mounted.
Conventional TOC analyzers for pure water utilize mercury UV lamps as the light source within the instrument. To provide a more environmental-friendly alternative, the eTOC series is the first analyzer in the world to use an excimer (short for ‘excited dimer’) lamp rather than a mercury lamp.
The “Active-Path” flow line design maximizes lamp power by integrating the sample flow channel and the light source. This minimizes sample residue in the flow channel and eliminates interfering air layers, so high sensitivity is maintained over long-term use. This new design also contributes to making the eTOC series instruments small and light.
Features
The TOC-1000e combines high-sensitivity and easy-to-use features benefiting effortless data management, efficiency and handling.
Some of the features include:
The TOC-1000e provides high sensitivity with a detection limit of 0.1 μg/L. It is housed in the world’s smallest and lightest cabinet and equipped with the industry’s largest color touch panel, providing exceptional visibility, simplifying operation and allowing effortless management of compliance relevant data. In addition, the novel fluid system minimizes sample residue in the flow channel, ensuring that high sensitivity is maintained.
The eTOC series has a simple design, and parts typically do not need to be replaced for one year; this increases efficiency by reducing maintenance and re-validation effort. Consumable parts (excimer lamp and pump head) can be removed and installed without tools. Using an optional sampler, the analyzer can be calibrated or validated (confirmation of manufacturing process validity) at the operating site. Certified standard solutions particularly for this series are available; they save customers the time and expense of purchasing and preparing items from a reagent manufacturer, and reduce mistakes caused by human error. In addition to analog interface and digital I/O, measurement data can be output to a printer or USB flash drive, or browsed and acquired via a built-in web server.
eTOC’s highly sensitive UV oxidation-conductivity method for ultra-pure water monitoring is compliant with regulatory requirements such as the United States (USP) and the European Pharmacopeia (EP). Inbuilt security functions including user authentication and audit trail, support compliance with regulations such as FDA 21 CFR Part 11. The LabSolutions software platform provides integrated management of the measurement data together with data and electronic signature functions (ER/ES) from laboratory TOC analyzers and other analytical instruments.
For more information, visit: https://www.shimadzu.eu/toc-analysis/etocseries
Porvair’s hydrophilic porous plastic components offer cutting-edge filtration
Laboratory, /in Product News /by panglobalVyon porous plastic discs and annular absorbers manufactured to extremely tight tolerances by Porvair Sciences offer cutting-edge filtration and separation of materials for healthcare, pharmaceutical and life science applications.
Drawing upon a wealth of knowledge in the manufacture of industry-leading porous plastics, combined with advanced materials expertise, Porvair Sciences has established a reputation for delivering outstanding hydrophilic components to OEM customers worldwide.
Employing precision moulding and die cutting processes, Porvair Sciences can efficiently convert hydrophilic Vyon® porous plastic into discs and annular shaped parts to tightly toleranced specifications. These versatile approaches enable Porvair to offer high performing, precisely manufactured products in diameters ranging from 3 mm to 1 metre using any of its hydrophilic Vyon materials options up to 4.75 mm thick.
Hydrophilically-treated Vyon materials have exceptional absorption and fluid transfer properties and therefore, can be implemented as an efficient absorber with its instantaneous wetting properties.
Due to the tortuous path of its porous structure, hydrophilic Vyon can efficiently filter and trap contaminants while allowing for effective delivery of drugs in various forms like solutions, suspensions and emulsions.
Hydrophilic Vyon has been tested to the most rigorous of USP classes and certified with a Class VI approval. Widely used in drug delivery and rapid diagnostic testing applications, its biocompatibility makes Vyon the ideal porous plastic material for healthcare, life science and pharmaceutical applications.
AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus manufacturing
Laboratory, /in Product News /by panglobalManufactured in dedicated clean-rooms with mandated changeovers before new production cycles – AMSBIO introduces new pHelper-Kan plasmid DNA optimized for Adeno-Associated Virus (AAV) manufacturing.
Adeno-associated virus is a non-enveloped virus that can be engineered to efficiently deliver DNA sequences of interest into target cells with a low immunogenicity. Because of these unique characteristics, AAV-mediated genome editing has emerged as a highly promising gene delivery method.
The robust virus packaging productivity of this pHelper-Kan plasmid has been tested in almost all AAV serotypes. pHelper-Kan is proven for use in daily AAV production, for both GMP grade and research grade batches.
Immediately available, premanufactured in stock, AMSBIO pHelper-Kan plasmid reduces the optimization work required to obtain high efficacy when producing viral vectors. The high reproducible quality of the pHelper-Kan plasmid DNA is maintained and verified by the company’s standardized manufacturing technology.
AMSBIO also provides a custom service to make ready-to-use AAV for any specific gene, shRNA or miRNA. Working closely with customers, AMSBIO will sub-clone your selected genes into their AAV expression vectors and produce expression AAV for each gene.
https://www.amsbio.com/phelper-kan-gmp-readytm-helper-plasmid-for-aav-packaging-gr-phelper-kan-v1