8 PRODUCT SHIMADZU

Shimadzu releases new Advanced i-Series liquid chromatographs

Shimadzu, one of the world leaders in analytical instrumentation, has released its “Advanced i-Series” liquid chromatographs. The Prominence-i HPLC and Nexera-i UHPLC systems feature pressures of 50 MPa or 70 MPa respectively and can be combined with a variety of detectors. The Advanced i-Series meets user demands for analyzing a large number of samples or […]

1 FEATURED CLINICAL MICROBIOLOGY

Spitting for the detection of SARS-CoV-2: is the juice worth the squeeze?

by Dr T. Truong, Dr J. Dien Bard and Dr R. Yee Nasopharyngeal swabs are recommended as the preferred sample type for detecting infection with SARS-CoV-2. However, there has been considerable interest in other collection methods, especially if they can circumvent supply shortages and the requirement for trained healthcare workers to administer them. Here we […]

10 PRODUCT HORIBA

Horiba Medical obtains CE Mark for new generation Microsemi CRP LC-767G

Horiba Medical, specialists in automated in vitro diagnostic systems for haematology, haemostasis and clinical chemistry analysis, has obtained the CE Mark certification for its new generation of the Microsemi CRP haematology analyser, the Microsemi CRP LC-767G.

2 FEATURED CARDIAC

The role of protein S-acylation in cardiac function

by Dr O. Robertson-Gray and Dr W. Fuller Cardiovascular disease (CVD) is the umbrella term for conditions affecting the heart or blood vessels and remains the leading cause of death worldwide. New therapeutic strategies to aid in the prevention and treatment of CVD are therefore necessary. This article discusses the potential for S-acylation, a post-translational […]

3 FEATURED CLINICAL MASS

Separation and characterization of viruses using multi-detector field-flow fractionation

by Dr Robert Reed and Dr Soheyl Tadjiki Viruses are increasingly used as gene therapy vectors in modern medicine. In order to minimize unwanted side effects such as immunogenicity, accurate determination of viral aggregation status is important. Field-flow fractionation is emerging as one of the most robust techniques for the separation and size measurement of […]

11 PRODUCT WATERS

Waters introduces Acquity Premier liquid chromatography solution

Waters Corporation has introduced the Waters Acquity Premier Solution, the next generation in liquid chromatographs featuring Waters’ breakthrough MaxPeak High Performance Surface (HPS) technology. The solution leverages HPS to vastly improve analytical data quality and eliminate the need for timeconsuming and costly passivation.

1A PRODUCT NOVA

AMSBIO offers mutant spike proteins, antigens for SARS-CoV-2 variant research

AMSBIO has introduced a collection of mutated SARS-CoV-2 spike proteins and recombinant antigens for the new virus variants – B.1.1.7 and B.1.351. These reagents can be used by researchers to evaluate the efficacy of the antibodies and identify targets for development of improved therapeutic drugs and vaccines.

4 FEATURED DRUGS

Carbohydrate-deficient transferrin testing: a truly traceable and specific biomarker for chronic alcohol misuse

by Jean Deenmamode The concept of testing breath, blood or urine for alcohol is familiar to the general public, and blood alcohol testing is widely used across a range of industries, from aviation to driver licensing. But is a snapshot alcohol measurement really the best approach to ensuring longterm safety in these industries, or identifying […]

5 FEATURED TECHNOLOGY

Choosing the correct tip for your pipettes: are third-party manufactured tips a good alternative?

by Dr Nicolas Gerst Pipettes are important tools widely used in the lab. They are usually chosen and purchased carefully with the goal of receiving the best performance for a given price. Pipette tips are consumables; therefore, price can be an important factor, sometimes at the detriment of quality and performance. We found that tips […]

Thermo Scientific introduces the Orbitrap Exploris GC 240

Thermo Scientific introduces Orbitrap Exploris GC 240 mass spectrometer

Thermo Scientific introduces the Orbitrap Exploris GC 240

Thermo Scientific has introduced the Orbitrap Exploris GC 240 – a new gas chromatography (GC) high-resolution mass spectrometer (MS) with unrivalled mass resolving power, sensitivity and wide dynamic range.

The GC addresses the need for increased flexibility, speed and accuracy in research applications throughout academic and industry laboratories, and offers researchers the capability to achieve new depths of analysis and drive scientific understanding. With new-generation system architecture and instrument control software, the system provides simple yet powerful data acquisition capabilities.

Research power

The  Orbitrap Exploris GC 240 MS takes research capabilities to a new level with a resolving power of 240,000, for accelerated innovation. By delivering both quantitative and qualitative information from a single injection, the new system enables precise and comprehensive compound identification, allowing researchers to make fast and accurate discoveries with confidence. As research laboratories require the versatility to answer myriad questions in their studies, the Orbitrap Exploris GC 240 MS also provides the flexibility to tackle a diverse range of analytical challenges, from identifying unknown contaminants and extractables and leachables, to applied quantification and metabolomics. The system offers the capability of MS/MS for compound structural information and both electron and chemical ionization without system venting to speed up time to result.

User benefits

Users of the Orbitrap Exploris GC 240 MS will benefit from:

  • Analytical dynamic range across six orders, providing accurate quantitation and detection of chemical components at trace and high concentrations
  • Standardized setup and easy-to-use system for users with varied levels of technical experience
  • Informatics solutions for targeted quantitation and profiling, such as the Thermo Scientific Chromeleon Chromatography Data System (CDS) software, which enables seamless data acquisition to reporting in targeted analysis. For profiling and discovery, the Thermo Scientific Compound Discoverer 3.2software enables researchers to discover sample differences, perform spectral matching and make proposed identifications of unknown compounds
  • Use of commercially-available spectral libraries for spectral matching, plus the use of application-specific high resolution accurate mass libraries in the Thermo Scientific Orbitrap GC-MS contaminants library and the Thermo Scientific Orbitrap GC-MS HRAM metabolomics library
  • Compact platform with a smaller footprint than existing systems.

Orbitrap Exploris portfolio

The new system, along with the Thermo Scientific Orbitrap Exploris GC, extends the Thermo Scientific Orbitrap Exploris portfolio of high-resolution accurate mass systems, which is now comprised of the Thermo Scientific Orbitrap Exploris 480 mass spectrometer, launched in 2019, and the recently introduced Thermo Scientific Orbitrap Exploris 240 and Thermo Scientific Orbitrap Exploris 120 mass spectrometers.