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In response to the global COVID-19 pandemic, Beckman Coulter, a global leader in clinical diagnostics, announced 31 March that it is developing assays to identify IgM and IgG antibodies to SARS-CoV-2. Research has shown that after infection with SARS-CoV-2, viral antigens stimulate the body’s immune system to produce antibodies that can be detected with IgM […]
Point-of-care (POC) testing has the potential to provide results in a much shorter time than centralized lab testing, allowing faster implementation of appropriate treatment. This article discusses the technological developments in POC tests, considerations for the implementation of a POC system, as well as how to ensure accurate and reliable results.
The new coronavirus, SARS-CoV-2, causing a disease that has been called COVID-19, was first identified in Wuhan, China in December 2019, and has been transmitted widely across the globe. This article gives a general overview of what is currently known in a fast developing situation.
Cardiac troponin is the gold standard biomarker for diagnosis of acute myocardial infarction. The introduction of high-sensitive cardiac troponin assays has further strengthened its power in early rule-in/rule-out testing. However, since these assays are susceptible to hemolysis interference, sample rejection due to hemolysis (commonly seen in samples from the Emergency Department) remains one of the […]
Current mass-spectrometry-based strategies will allow us to understand the molecular phenotypes of disease, which will drastically improve the diagnostic power of new clinical tests. In this interview, Professor Cobbaert [head of the Department of Clinical Chemistry and Laboratory Medicine at the Leiden University Medical Center (LUMC), Leiden, The Netherlands] and Dr Van der Burgt (associate […]
Before starting cancer treatment with fluoropyrimidine-based chemotherapies, it is highly recommended to check for dihydropyrimidine dehydrogenase (DPD) deficiency by measuring uracilemia (or calculating the dihydrouracil:uracil ratio). This article discusses some of the ways of doing this. Background Approved for treatment of humans 60 years ago, fluoropyrimidinebased chemotherapies remain important antineoplastic agents. They are widely used […]
Owlstone Medical and Thermo Fisher Scientific recently announced a collaborative partnership to advance the early diagnosis of cancer and other diseases. This will involve the integration of Orbitrap gas chromatography mass spectrometry (GC-MS) instrumentation into Owlstone Medical’s Breath Biopsy platform, aiding metabolomics studies of breath samples for unique biomarkers that could translate into non-invasive, routine […]
OXGENE and The Native Antigen Company are collaborating to scale up production of SARS-CoV-2 reagents by combining OXGENE’s proprietary Adenoviral Protein Machine Technology with The Native Antigen Company’s antigen development expertise. Together, they aim to scale their antigen manufacturing capabilities to deliver high-purity, recombinant proteins for the development of diagnostics and vaccines. Unlike the PCR […]
UK-based PCR Biosystems issued a statement 1 April saying they are continuing to scale up operations to ensure the critical enzyme mix for COVID-19 tests remain available to the UK and global healthcare systems as demand for testing rises. To meet current and upcoming requirements and ensure supply chain security, PCR Biosystems has already significantly […]
Siemens Healthineers’s latest critical care testing solution, the RAPIDPoint® 500e Blood Gas Analyzer, has received clearance from the U.S. FDA, and is now available in the U.S., Europe and countries requiring the CE mark. The analyser generates blood gas, electrolyte, metabolite, CO-oximetry, and neonatal bilirubin results, which are used to diagnose and monitor critically ill […]
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