Thermo Scientific™ system reagents are specifically developed and optimized for Indiko™ and Konelab™, random access clinical chemistry analyzers. Over 70 ready-to-go reagents mean ease of use, saving operator’s time and minimizing risk of errors. Reagent vessels are bar-coded so that reagent consumption and expiry date can be automatically monitored in real-time. Volume optimized kit sizes and on-board stability minimizes the amount of waste increasing cost-efficiency. The latest addition to Konelab specific protein system reagents is soluble transferrin receptor (sTfR). Method used is latex enhanced immunoturdimetry measured at 575 nm. The kit size is up to 200 tests. The application is CE marked and tested with system calibration set and quality controls. Fully validated and tested application protocols deliver confidence in testing accuracy and precision. Fully automated Indiko and Konelab platforms cover various testing needs ranging from routine clinical chemistry into immunoassays for drugs of abuse screening, therapeutic and immunosuppressant drug monitoring.
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Designed for the measurement of AIF-1 in human serum and plasma, the innovative AIF-1 ELISA is suitable for the determination of a novel biomarker relevant particularly to the risk of transplant rejection or vasculopathy and graft versus host disease. Allograft inflammatory factor-1 (AIF-1) is an interferon gamma-inducible cytoplasmic protein constitutively expressed in inflammatory cells and inducible in vascular smooth muscle cells in response to injury or inflammatory stimuli, including rejection or balloon angioplasty. Its expression correlates with cardiac rejection and the development of cardiac allograft vasculopathy. AIF-1 expression levels and protein concentrations were also studied in atherosclerosis, nephritis, arthritis, breast cancer and others. The BioVendor assay meets all the requirements for the routine clinical use in manual manner as well as on open ELISA robotic systems.
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The Dx Prep System and Dx Real-Time System combine high quality nucleic acid extraction (magnetic beads), PCR set up, and advanced multiplex realtime PCR. This CE-IVD automation offers a flexible batch size of up to 96 tests without tip or reagent overconsumption, a full traceability of samples and reagents and a complete process monitoring from sample to result. With their intuitive user interface, ergonomic design and minimal maintenance, the Dx Systems can easily be implemented in any laboratory. With this automation, Bio-Rad introduces the Dx CT/ NG/MG Auto Assay and the Dx HR-HPV Auto Assay, designed to offer excellent performance, full-control process and minimal hands-on time with their ready-to-use reagents. The availability of the open channel on the Dx Real-Time System further extends the range of applications.
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The hallmark of H. pylori infection is inflammation of the gastric mucosa. While gastritis is typically subclinical, more severe consequences of infection include mucosa associated lymphoid tissue (MALT) lymphoma, gastric carcinoma and peptic ulceration. Nearly all patients with gastric MALT lymphoma are infected with H. pylori, and the risk of developing this tumour is over six times higher in infected people than in uninfected people. Furthermore, up to eighty percent of patients with gastric MALT lymphoma achieve complete remission of their tumours after treatment with H. pylori-eradicating antibiotic therapy. Several aspects such as performance, costs, time, and feasibility should be considered in the selection of the diagnostic tests for H. pylori infection. However, invasive and intense methods are not suitable simply because of their invasive nature. The clinically accepted C-UBT test are expensive, H. pylori stool antigen tests are cumbersome and time consuming and most of the serologic tests cannot differentiate between current and non-current H. pylori infection. MP Diagnostics has developed CIM (Current Infection Marker) that detects a H. pylori specific protein. The benefits of CIM (high correlation with known gold standards, high positive predictive value of > 90% as well as detection of active H. pylori infections) provided by the ASSURE® H. pylori rapid test are also to be found in the Helico Blot 2.1 confirmatory western blot.
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The BÜHLMANN Calprotectin ELISA that provides a dynamic measuring range of 10-1800 μg/g now offers newly developed and thoroughly validated protocols for various ELISA automated analysers from numerous manufacturers, including CE-marked application protocols for the Dynex DS2 and the Dynex DSX. This enables running the BÜHLMANN Calprotectin ELISA in high throughput with high reliability for the diagnosis and therapy followup of inflammatory bowel disease (IBD) patients. With this latest development a further step is taken towards harmonization of calprotectin test results, allowing even better comparability between labs worldwide.
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