The DuraClone RE* antibody panels provide tools to study low frequency populations of either abnormal CD5+ B cells (RE CLB), abnormal plasma cells (RE PC) or abnormal B progenitor cells (RE ALB). The three new standardized, pre-formulated DuraClone RE* kits deliver high sensitivity for rare cell populations, able to accommodate either large sample volumes or high cellular concentrations. Using dry, unitized antibody combinations helps preserve the strict assay conditions essential for reliable, reproducible rare event analysis. The DuraClone family of dry reagents simplifies sample preparation and handling. The panels eliminate errors from manual antibody pipetting, streamline workflow, improve turnaround time (TAT) and simplify inventory management. The kits are stable at room temperature, even when opened, and easy to transfer between laboratories. The first Duraclone standardized dry, pre-formulated panels were introduced in 2014, to support research into the human immune system. Since then, the company has added DuraClone IM and IF panels for investigating immune profiles and function. While preserving strict assay conditions, which is integral to rare event analysis, the DuraClone RE* kits, produced in collaboration with experts from leading clinical research laboratories, enable streamlined workflow and standardization of results that are essential to the experimental robustness of longitudinal and multi-centric research into blood disorders. Internationally-recognized German clinical research scientists commented that the inclusion in the DuraClone RE CLB panels of ROR-1 as a new discriminative marker has markedly facilitated the screening for low frequencies of abnormal B cells and also that the DuraClone Panels provide a sensitive, analytically reliable and economic tool for the detection of minute, abnormal, plasma cell populations. DuraClone RE antibody panels are available in a convenient 25-test package containing three complete compensation kits specific for each panel. They offer the flexibility of additional antibody drop-in slots, making it possible to answer a customer’s specific questions. Further additions to the DuraClone product family are in development, including dry stimulation cocktails for functional assays.
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Real-time incubator and colony counter
, /in Product News /by 3wmediaThe ScanStation is a real-time incubator and colony counting station designed for the pharmaceutical, agro-food and cosmetic industries as well as research. It provides centralized incubation, detection and colony counting of 100 Petri dishes simultaneously. In classical Pasteurian microbiology, the Petri dish must be placed in an incubator for 24h and up to 5 days. Then a time-consuming reading operation is performed to count colonies. The operator may notice the presence of invasive or confluent colonies mixed with air bubbles or debris, increasing the margin of error on the final result. The ScanStation provides results as soon as 6 hours after the beginning of the incubation which is up to 3 times sooner, faster and with unequalled accuracy. The ScanStation detects and counts colonies as soon as they appear at the beginning of the incubation. It is a real-time process, providing anticipated results, saving time and allowing earlier release of production batches. With this new technology, microbiologists can actually see, in real-time, the video of bacterial growth on the Petri dishes. This innovation is a mix between classic methods with the Petri dish and the latest innovations in robotic and computing, providing analyses’ results with unequalled accuracy and much sooner. The major innovation of the ScanStation is the automatic counting of the colonies at an early stage of their development, starting at the beginning of the incubation cycle. Up to 100 Petri dishes are counted every 30 minutes throughout the process, delivering a video recording of the bacterial growth. Final results are known 3 times sooner and faster because up to 100 Petri dishes are processed simultaneously and with superior accuracy as colonies are detected before clustering or covering can occur.
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Heart FABP (FABP3) ELISA
, /in Product News /by 3wmediaH-FABP (Heart fatty acid binding protein, FABP3) is a sensitive biomarker for myocardial infarction (MI). H-FABP is released from cardiac myocytes following an ischemic episode and can be detected in the blood within one to three hours of chest pain onset. To identify myocardial infarction and acute coronary syndrome, a combination of H-FABP with troponin shows increased sensitivity over troponin alone in patients with chest pain onset. H-FABP also has prognostic value, as it is proved to be a statistically significant predictor of death or MI, independent of troponin T, ECG and clinical examination. The FABP3 assay has been validated for human serum, plasma, urine, cerebrospinal fluid, bronchoalveolar lavage fluid, amniotic fluid and tissue homogenates and has a very high sensitivity (LOD 5.6 pg/ml). H-FABP is a small cytosolic protein expressed predominantly in the cardiac myocytes; it is found at much lower levels in skeletal muscle, kidney, liver and small intestine. H-FABP can quickly pass through the kidney and be measured noninvasively in urine.
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Automated hematology cellular analysis workstation
, /in Product News /by 3wmediaThe Mindray CAL 6000 is a benchtop cellular analysis line that connects two units of the BC-6000 or BC-6200 auto hematology analysers and the SC-120 auto slide maker and stainer. The compact streamlined workstation helps save more laboratory space and delivers fast throughput of up to 220 samples and 120 slides per hour. It provides automated body fluids test results, including peritoneal fluid, pleural fluid, CSF and synovial fluid. The CAL 6000 is equipped with labXpert software as standard configuration for professional data analysis, enabling automatic sample validation and analysis.
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Discriminating antibody panels for rare event detection
, /in Product News /by 3wmediaThe DuraClone RE* antibody panels provide tools to study low frequency populations of either abnormal CD5+ B cells (RE CLB), abnormal plasma cells (RE PC) or abnormal B progenitor cells (RE ALB). The three new standardized, pre-formulated DuraClone RE* kits deliver high sensitivity for rare cell populations, able to accommodate either large sample volumes or high cellular concentrations. Using dry, unitized antibody combinations helps preserve the strict assay conditions essential for reliable, reproducible rare event analysis. The DuraClone family of dry reagents simplifies sample preparation and handling. The panels eliminate errors from manual antibody pipetting, streamline workflow, improve turnaround time (TAT) and simplify inventory management. The kits are stable at room temperature, even when opened, and easy to transfer between laboratories. The first Duraclone standardized dry, pre-formulated panels were introduced in 2014, to support research into the human immune system. Since then, the company has added DuraClone IM and IF panels for investigating immune profiles and function. While preserving strict assay conditions, which is integral to rare event analysis, the DuraClone RE* kits, produced in collaboration with experts from leading clinical research laboratories, enable streamlined workflow and standardization of results that are essential to the experimental robustness of longitudinal and multi-centric research into blood disorders. Internationally-recognized German clinical research scientists commented that the inclusion in the DuraClone RE CLB panels of ROR-1 as a new discriminative marker has markedly facilitated the screening for low frequencies of abnormal B cells and also that the DuraClone Panels provide a sensitive, analytically reliable and economic tool for the detection of minute, abnormal, plasma cell populations. DuraClone RE antibody panels are available in a convenient 25-test package containing three complete compensation kits specific for each panel. They offer the flexibility of additional antibody drop-in slots, making it possible to answer a customer’s specific questions. Further additions to the DuraClone product family are in development, including dry stimulation cocktails for functional assays.
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Fluorescence reader for multiplex assays
, /in Product News /by 3wmediaThe sciREADER FL2 offers a high resolution imaging technology and easy data analysis inherited from the company’s sciREADER CL2. Equipped with up to 3 fluorescent channels it can be applied for all commonly used blue, green and red fluorescent dyes that are excited using LEDs with specific wavelengths. It’s the only reader on the market which allows for high quality imaging of 96 well plates for standard fluorescence single parameter assays and multiplexed arrays. Operators benefit from exceptional ease of use software including automated spot finding, image analysis and evaluation of single arrays or array batches. Customization of array layout, analysis and reporting makes it a suitable tool for clinical diagnostics and life science research. With the seamless integration of spotting patterns like GAL files and unique software features for spot adjustment, re-analysis and interpretation of analysis results, the sciREADER FL2 offers a complete solution for multiplexed diagnostics.
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Comprehensive offering of disease state sera
, /in Product News /by 3wmediaBinding Site’s Immunologicals Group features a comprehensive offering of disease state sera in its broad portfolio of products available to in-vitro diagnostic (IVD) manufacturers and clinical/life science research facilities. The availability of these essential, but frequently overlooked constituent products, will benefit the needs of many allied health professionals, as both their sourcing and availability have been historically problematic.
Following all current regulatory and quality standards guidelines, the company is able to provide materials from a wide variety of disease state conditions – including ANA’s; ANCA’s; aPL’s; ENA’s; infectious/contagious diseases; inflammation markers; and auto-antibodies focused on a variety of human organs and tissues. All of these materials are available in bulk formats with volumes ranging in excess of litres for use in the manufacturing of calibration and/or quality control materials. Smaller volumes may be available upon request. In addition, as the primary source supplier of these products, the company can offer comprehensive data on analyte-positive as well as negative data, along with a comprehensive Certificate of Analysis.
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Microscope camera
, /in Product News /by 3wmediaOptimized for sharing, documenting and publishing, the fast 18-megapixel SC180 camera uses the full optical resolution of the microscope and produces clear, crisp images at all magnifications. The 4K UHD live image helps to engage audiences in large-screen presentations and to increase throughput in tissue documentation and creating detailed images for publication. The SC180 camera provides the benefits of 4K microscopy which enables users to get the same level of detail on the screen as through the oculars and shows true-to-life structures and colours for enhanced sample observation. To guarantee the highest quality of images, the SC180 camera offers fully automated, real-time image processing features. Olympus Smart Image Averaging (OSIA) reduces noise for crisp, clean images; real-time colour profiling with automated white point calibration ensures natural-looking colours for reliable images. Speeding up routine imaging, the SC180 also has Focus Peaking technology as well as a Fast Live function to improve throughput and productivity. Focus Peaking enables users to see which areas of a specimen are exactly in focus and get the desired image with the first click. Fast Live maintains a high frame rate when the specimen is being moved to ensure comfortable, fluid navigation regardless of the illumination conditions.
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Improved PT reagent
, /in Product News /by 3wmediaThe Prothrombin Time test is the cornerstone of the coagulation discipline, representing over 50% of tests performed worldwide. Using a LEAN-based approach to cost reduction and improved patient safety, STA-NeoPTimal is a high performing PT reagent which is adapted to all types of laboratory workflows. For an optimal management, the new reagent offers a flexible solution with a range of 3 packaging sizes (5, 10 and 20 mL). It is the only tissue-extract PT and precalibrated reagent with an ISI = 1, with instrument-specific ISI values assayed against international standards and optimal sensitivity to changes in factor concentrations. The ease-of-use STA-NeoPTimal reagent offers user confidence and safety thanks to a fully validated system: fully automated barcoded reagent management with QC ranges for all Stago analysers and validated for evaluation of exogenous factors (II, V, VII and X); automatic Mean Normal Prothrombin Time (MNPT) calculation with STA Coag Expert module and a unique Viscosity-based Detection System (VBDS) insensitive to analytical interferences, such as hemolysis, icterus and lipelmia (HIL samples).
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Blood gas testing system
, /in Product News /by 3wmediaThe GEM Premier 5000 whole blood testing system measures blood gases, pH, electrolytes, metabolites, CO-Oximetry and more. iQM2 (/en/intelligent-quality-management-2-iqm2) provides real-time assurance, the all-in-one, multi-use GEM PAK offers advanced simplicity and GEMweb Plus Custom Connectivity allows complete control of point-of-care testing.
iQM2 with IntraSpect technology provides intelligent analysing – automated quality assurance, continuously and in real-time, unlike traditional (auto or manual) QC offerings. With real-time detection, iQM2 performs continuous checks – before, during and after every sample. Error detection time is reduced from hours to minutes and errors automatically corrected and documented for a complete picture of quality with each and every sample. This ensures accuracy of results, regardless of point-of-care operator, time or place.
All-in-one, multi-use, GEM PAK offers advanced simplicity at every point-of-care. Fully self-contained, the GEM PAK automates the most labour-and skill-intensive processes and is available in multiple menu and test volume configurations, GEM PAKs have a use-life of 31-days and require no refrigeration. They allow ultimate flexibility for point-of-care testing needs throughout the hospital.
GEMweb Plus 500 Custom Connectivity is designed to simplify operator supervision and quality management with full traceability. All from a single interface, whether accessed in the lab, at the point-of-care or remotely from an analyser, PC or tablet device, GEMweb Plus 500 provides customizable and automated functionality for complete control of analysers and operators.
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Analyser with integrated cooling system
, /in Product News /by 3wmediaA new version of the A15, a benchtop analyser with a throughput of 150 tests per hour featuring simplicity, high flexibility and analytical robustness, is available now with a new integrated cooling system to increase on-board reagent stability. This new optional configuration guarantees high reagent stability even for those laboratories working in continuous mode, as well as simplifying reagent handling for those that prefer to keep reagents on board. The new cooling system, with a capacity of up to 20 reagents on board in any combination of 20 and 50 mL vials, is able to maintain them at 10ºC below room temperature. It provides increasing stability for those reagents known to be affected by variations or high room temperatures, reducing time required to reagent preparation while facilitating reagent configuration steps. The company also provides a wide range of dedicated and validated reagents, designed to achieve optimal analytical performance when used with its analysers.
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