The new DxC 700 AU chemistry analyser brings together the advanced capabilities of two successful Beckman Coulter products – the simple intuitive design of the DxC analyser and the robust throughput and workhorse capabilities of the AU analyser – into one standardized platform designed to meet the needs of mid- to high-volume clinical laboratories. Additionally, by gaining further input from the clinical laboratory professionals, who are under pressure daily to produce faster results and manage resources more efficiently, additional features and benefits were identified and designed into the product. The DxC 700 AU chemistry analyser reduces the number of test-processing steps by 30%, streamlining workflow for laboratory professionals. The reduction in steps is the result of powerful operating software, an all-new design and an intuitive user-interface that allow operators to spend less time on daily tasks and more time producing the quality results that empower better decision-making for better patient care. The new software is easy to learn and simple to operate with very little experience. The ability to load reagents ‘on-the-fly,’ while the instrument is running, saves time and minimizes disruption to workflow. Along with its efficiency, the DxC 700 AU analyser reduces total cost of ownership by using fewer consumables compared to other industry same-class systems. Additionally, the system uses concentrated reagents, longlasting ion-selective electrodes (ISEs), and non-disposable cuvettes to help laboratory specialists achieve financial goals and manage resources. The system is further designed for time- and cost-savings superior uptime through the Beckman Coulter “3 & 60” concept. The “3 & 60” concept gives laboratory staff the ability to change out replacement parts in three steps, within 60 seconds, with no tools. The DxC 700 AU analyser is part of Beckman Coulter’s Total Laboratory Solution, featuring a broader comprehensive portfolio that provides the flexibility to tailor systems based on a laboratory’s volume and space needs. Customers have access to an array of efficient solutions, including: the Power Link system, which connects small-footprint automation with chemistry and immunoassay analysers; the Power Express, a multi-discipline, tracked-based automation solution; and, Remisol or Command Central, both of which offer robust information data management capabilities. The DxC 700 AU system is currently available in the U.S. and will become available in other regions throughout the world in 2017.
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DiaSys offers an improved, liquid-stable and ready-to-use reagent for common clinical chemistry analysers. For the determination of ß-hydroxybutyrate (ß-HBUT) serum and plasma samples can be used. ß-HBUT is an important marker to detect diabetic ketoacidosis (DKA), a potentially life-threatening complication in diabetes mellitus, which can lead to coma or even death. The new ß-Hydroxybutyrate 21 FS offers a wide measuring range which ensures few sample repeats and therefore is time- and cost-saving. Interferences to endogenous and exogenous substances were minimized and calibration and on-board stability were prolonged to 12 weeks. The new ß-Hydroxybutyrate 21 FS is robust and provides accurate and highly reproducible results.

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Chromsystems launched MassChrom Metanephrines in Plasma new CE-IVD assays for the efficient quantification of metanephrine, normetanephrine and 3-methoxytyramine by LC-MS/MS. The kits are available in two configurations, either with sample clean up columns or 96 SPE well plates. The assays encompass all required components and enable a simple and fast sample preparation in just a few steps. The analytes are chromatographically separated, avoiding co-elution and minimizing the risk of interferences.  Stable isotope-labelled internal standards for every single analyte ensure a reproducible and reliable quantification. The 6PLUS1 Multilevel Calibrator Set and MassCheck controls are based on human plasma to minimize matrix-induced differences. MassChrom Metanephrines in Plasma complement the full range of CE-IVD assays from Chromsystems for the determination of biogenic amines. These include assays for HPLC and LC-MS/MS and in the plasma and urine matrices. Laboratories with higher sample throughput can also rely on the company’s automated systems.

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With a genuine throughput of 120 tests per hour for CBC including differential and nucleated RBCs, the Yumizen H2500 and Yumizen H1500 are able to absorb the workflow of laboratories with high activity. Both analysers are equipped with a three-dimensional count capable of combining the measurements of cellular complexity, volume and distribution for each of the leukocyte subpopulations. In order to manage leucopenic, thrombocytopenic and anemic samples, an integrated ‘low value’ cycle allows automatic readjustment of the counting constants. In addition, a new platelet determination system operates via two methods, impedance and optical extinction in separate channels. Also included is the company’s newest middleware, the Yumizen P8000, which allows laboratories to centralize data management and optimize automatic validation of results (customizable rules engine), while controlling productivity and real-time performance (connection status, maintenance, TAT, manual validation …). The Yumizen SPS can be optionally added to the Yumizen H2500 and allows fully automatic slide-making at a rate of 120 slides per hour. The Yumizen H2500 / H1500 + Yumizen SPS module are available as standalone units or combined in the HELO Solution (HELO = HORIBA Evolutive Laboratory Organization) allowing several instruments to be connected to the Yumizen T6000 high-speed tube conveyor.

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Beckman Coulter has significantly expanded the workflow capabilities of its AQUIOS CL Flow Cytometer with the addition of the AQUIOS Designer Software, developed specifically to handle user-defined tests in the routine lab. The AQUIOS Designer Software allows for the creation of customer-defined applications to be run on an instrument that combines sample preparation and flow cytometry analysis in one platform (AQUIOS Load & Go technology). Until recently, this feature combination was only available for pre-defined applications like CD4 analysis and basic immunophenotyping. With traditional flow cytometry, sample preparation and analysis required a two-step approach carried out on different instruments. Even with semi-automated processes this would slow down the lab’s overall productivity and cause bottlenecks. It also limited the role of flow cytometry technology in today’s lab, which requires 24/7, streamlined workflow and a consistent turnaround time (TAT). Many laboratories now create their own reagent cocktails for routine applications to accommodate the specific marker combinations required by their individual focus. The addition of AQUIOS Designer Software fundamentally changes the way flow cytometry technology performs within the routine lab.  It reduces the routine, repetitive task of having to manually mix reagent combinations.  Far greater workloads can be handled quickly and efficiently, without bottlenecks. The optional AQUIOS Designer Software provides an intuitive and user-friendly interface with powerful features to set up user-defined protocols, acquisition templates, panels, compensation settings, and the parameters needed for statistical and quality control compliance. All features can easily be accessed via pull-down menus or slider bars. On the small footprint, high precision AQUIOS CL Flow Cytometer, sample loading is as easy as on a hematology analyser, with integrated automated sample preparation. It delivers first results within 20 minutes for routine applications such as immunophenotyping, with subsequent sample results at a rate of approx. 25 samples per hour for up to a full 96-well plate for each test of Tetra Combo. The company provides the reagents for user-defined assays either through the Contract Manufacturing (GMP) or Custom Design Services of user-defined reagents. Either option provides barcoded and cap-pierceable vials that can be run on the AQUIOS CL instrument with automated tracking of all QC functionalities, including reagent type, container ID, and lot number.

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