Product News

AMSBIO introduces HER2 cell line array for breast cancer research

Laboratory, 26 April 2021/in Product News /by panglobal

AMSBIO has introduced a new HER2 control cell line array that is proven as an effective slide quality control for HER2 expression in breast cancer tissue samples.

This new FFPE cell pellet microarray delivers a full dynamic range of HER2, ER and PR expression, validated by the Ventana system, to give immunohistochemical data in strong concordance with the routinely processed tissue sample sections.

Using cell line controls significantly lower the costs of immunohistochemical (IHC) examinations and fluorescence in situ hybridization (FISH) while enabling high levels of standardization and reliability.

AMSBIO offer a wide range of high quality FFPE cancer cell line controls for researchers. Manufactured using a proprietary process that maintains both cell morphology and preserves nucleic acids and proteins, the AMSBIO range of FFPE cancer cell line products offer affordable and consistent controls from 100 tumor cell lines, without compromising quality or consistency. These cell line controls combat issues experienced with traditional cell or tissue-based control specimens such as intra specimen variation, lot-to-lot variations and inconsistent biomolecule quality. FFPE controls provide the most flexible cell-based products for immunohistochemistry, in situ hybridization and next generation screening applications.

For more information, visit: https://www.amsbio.com/ffpe-cancer-cell-line-controls/

ProBioGen licenses GlymaxX tech to Sanofi

Research, 26 April 2021/in E-News, Product News /by panglobal

Berlin-based ProBioGen AG has signed a commercial multi-product license agreement with Sanofi. Under the agreement, Sanofi will integrate ProBioGen’s proprietary GlymaxX technology into their product development strategy for an undisclosed number of antibody candidates across several business units.

GlymaxX enables a boost of antibody-dependent cell-mediated cytotoxicity (ADCC), consequently leading to an elevated NK cell mediated killing activity of its target cells. The GlymaxX technology adds value to the products by significantly improving their potency and potentially reducing the overall clinical doses for patients.

The GlymaxX technology for production of afucosylated proteins is widely applied in the pharma industry and hence used in various numbers of mAb candidates. It is universally applicable, simple and very potent.

The unique advantage of the GlymaxX technology allows a single GlymaxX modified cell line to produce both, completely fucosylated and/or afucosylated antibodies and those with intermediate defined fuscosylation levels.

The technology can be easily integrated in newly developed or already existing cell lines of different host cell origins, which demonstrates its great flexibility.

ProBioGen is a premier CDMO for developing and manufacturing complex therapeutic glycoproteins. The GlymaxX technology, developed by ProBioGen, prevents the addition of the sugar “fucose” to the N-linked antibody carbohydrate part by antibody producing cells. The absence of fucose enhances ADCC (antibody-dependent cell-mediated cytotoxicity) activity for antibodies directed against cancer and infectious diseases. The GlymaxX technology is based on the stable introduction of a gene for an enzyme which deflects the cellular pathway of fucose biosynthesis. ProBioGen offers this technology royalty-free to third parties.

For more information, see: http://www.glymaxx.com/

SARS-Cov_2 variants of concern - assays from Bio-Rad

Bio-Rad launches SARS-CoV-2 variant RT-PCR assays

Laboratory, Virology, 23 April 2021/in Product News /by panglobal

Bio-Rad Laboratories has introduced SARS-CoV-2 Variant RT-PCR Assays for research use only (RUO). The assays can detect SARS-CoV-2 variants of concern, including P.1, B.1.351, and B.1.1.7, by distinguishing specific mutations using reverse transcription PCR (RT-PCR) often prior to a next generation sequencing (NGS) workflow for confirmation.

With the emergence of several SARS-CoV-2 variants of concern, public health researchers are looking for a quicker way to track the spread of these variants in a population. Laboratories that use NGS to track COVID-19 variants can detect these mutations more quickly and cost-effectively with the SARS-CoV-2 Variant RT-PCR Assays to more rapidly prioritize which samples to submit for NGS.

For more information, visit: bio-rad.com/COVIDVariantSurveillance

total RNA extraction by Porvair Sciences

Porvair Sciences launches kits for rapid extraction of total RNA

Laboratory, 23 April 2021/in Product News /by panglobal

Porvair Sciences has launched new kits for rapid extraction of total RNA from a wide range of biological samples. These proprietary kits enable extraction of up to 1000 µg of application-ready pure RNA in as little as 10 minutes.

Extraction and purification of RNA is required for numerous downstream molecular biology applications such as RT-PCR, qPCR, Western blotting and RNA amplification. The global COVID-19 pandemic has resulted in a huge increase in the demand for testing and detection of viral nucleic acids. The first step in this process, no matter what research or testing method is to be used, is to extract the RNA from any sample with a potential viral contamination.

The new affordable and easy-to-use Chromatrap RNA Extraction kit from Porvair Sciences all follow the simple procedure of sample lysis, RNA capture, washing, and finally elution of purified RNA.

Leveraging a uniquely designed spin column and proprietary buffer chemistry, the Chromatrap RNA Extraction kit is the complete solution for isolation and purification of RNA. Providing the perfect high recovery of top-quality salt and contaminant-free RNA.

Porvair’s extraction kits employ a reliable protocol to isolate superior quality RNA from a wide range of samples sources. These kits benefit from high volume binding capacity which ensures RNA is efficiently lysed, captured and eluted.

The Chromatrap RNA Extraction kit is quick and easy to use, ensuring high recovery of high purity RNA during the first steps of fundamental molecular biology applications. Using a Chromatrap RNA extraction kit – scientists are now able to process up to 107 cultured animal cells, 50 mg animal tissue, 0.5 ml blood, 250 mg plant material, 5 x 107 yeasts or 5 x 108 bacteria in a single go.

For more information, visit: chromatrap.com/chromatrap-rna-extraction-kit/

Shimadzu’s iMScope QT wins Red Dot Design Award 2021

, 15 April 2021/in Product News /by panglobal

Shimadzu has been awarded a Red Dot Design Award 2021 in the product design category for its iMScope QT. It combines an LCMS-9030 Q-TOF mass spectrometry instrument with an optical microscope from the iMScope series, guaranteeing excellent speed, sensitivity and spatial resolution for data analysis. iMScope QT will soon be available for the European Market.

The Red Dot Design Award is one of three major international design awards, alongside the German iF Design Award and the US IDEA Award. The international panel of experts comprises specialists from a wide variety of sectors judging products based on innovation, functionality, quality, ergonomics and durability.

The iMScope QT is a newly developed instrument completing the Shimadzu iMScope series, enabling high performance MS imaging. It combines an LCMS-9030 Q-TOF mass spectrometry system with an optical microscope from the iMScope series to guarantee excellent speed, sensitivity and spatial resolution for data analysis

For more information, visit: www.shimadzu.eu

AMSBIO offers animal-free enzymes for in-vitro tissue dissociation

Laboratory, Research, 6 April 2021/in Product News /by panglobal

AMSBIO, in association with Nordmark Biochemicals, is now offering animal-free Collagenase and Neutral Protease enzymes, isolated from Clostridium histolyticum, for in-vitro tissue dissociation leading to high yields of viable cells.

Being animal-free, these enzymes are very safe and offer reduced regulatory hurdles for use in clinical applications. They are manufactured under GMP guidelines using a plant-based production process that guarantees no risk of cross-contamination with animal-derived materials. These top-quality enzymes can be used on a wide range of cell/tissue types and are supported with specific protocols available based on each application.

Highly consistent, top quality Collagenase and Neutral Protease are essential tissue dissociation enzymes for tissue engineering and regenerative medicine applications. In addition to the animal-free enzymes, this product portfolio includes a comprehensive range of Collagenase and Neutral Protease enzymes manufactured under GMP guidelines with certified TSE safety and virus validation studies carried out for each batch. The high level of quality control involved in the production of these enzymes means that they have reliable lot-to-lot consistency with accurate analysis of proteolytic enzyme activities.

AMSBIO also offers research grade Collagenase and Neutral Protease enzymes. These research grade enzymes are available with a wide range of enzymatic activities, from standard collagenases, offering balanced amounts of other proteolytic activities, to highly purified collagenases. As each application requires different digestion conditions, this large range of Collagenase NB products offers optimal digestion conditions for a wide variety of tissue types.

To help you find the right enzyme and specific protocol best suited to your choice of cells and tissues, and thereby ensure consistent optimized results, AMSBIO has established an online resource at: https://www.amsbio.com/collagenase-nb-and-neutral-protease/.

Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator

Laboratory, Research, 6 April 2021/in Product News /by panglobal

Porvair Sciences’ Ultravap Levante nitrogen blowdown sample evaporator

Porvair Sciences has launched its new generation Ultravap Levante nitrogen blowdown sample evaporator.

The second generation system offers the many benefits associated with Porvair’s flagship evaporator, the Ultravap Mistral, in an affordable, easy-to-use package. This state-of-the-art single microplate evaporator is designed to meet the current needs of most chromatography laboratories whilst providing the future option of fully automating sample dry-down in applications such as LC/MS analysis, dry recovery or reconstitution.

The compact, standalone Ultravap Levante is fully programmable and easy to control from a robot liquid handler. Its advanced head technology enables delivery of evaporation temperatures up to 80°C for faster solvent evaporation rates. If required the system has the option to be fitted with ducted fan fume extraction.

Operated via an intuitive graphical colour LED touchscreen, software features includes up to 5 stored alphanumerically named programs and multi-step evaporation programs. This functionality combined with real-time run displays showing actual gas temperature, gas flow rate and stage height means the Ultravap Levante puts you in full control of the evaporation process. A removable acrylic splash guard safeguards the operator and also ensures efficient removal of the solvent vapour from the evaporation table.

The Ultravap Levante is supplied with an evaporator head of your choice, which may be interchanged quickly and easily with a head of a different pattern as your workflow demands.

The precision engineered mechanism uses a standard ANSI/SLAS plate nest to accept most microplate formats and tube racks. It can accommodate tubes up to 50 mm in height in a variety of configurations to allow the use of 2 Dram vials, 1.5 ml HPLC vials, bar-coded tubes in racks and many other common formats. Evaporator heads are available for efficient dry down of 24-, 48-, 96- and 384-well microplates at temperatures up to 80°C

The Ultravap Levante can be operated from both a gas cylinder and an in-house supply of nitrogen or clean dry air. The blow-down evaporation technique is well proven for efficiently removing chromatography solvents such as dichloromethane, acetonitrile, methanol and hexane.

For more information, visit: https://www.microplates.com/blowdown-evaporator-ultravap-levante/

Nova blood gas analysers add important new test – estimated plasma volume

, 29 March 2021/in Product News /by Nova Biomedical Corp.

Nova Biomedical has added a key new test to its Stat Profile Prime Plus critical care analyser – the ability to calculate and report estimated plasma volume (ePV), a very important test for critically ill patients but one that has been very difficult to obtain. The plasma volume status of a patient is one of […]

Beckman Coulter’s SARS-CoV-2 IgG II antibody test approved in countries accepting CE Mark

, 29 March 2021/in Product News /by Beckman Coulter International

Beckman Coulter’s Access SARS-CoV-2 IgG II assay is now available in countries accepting the CE Mark. The new Access SARS-CoV-2 IgG II assay quantitatively measures a patient’s level of antibodies in response to a previous SARS-CoV-2 infection. The ability to establish a quantitative baseline to evaluate an individual’s immune response to the SARSCoV- 2 virus […]

ERBA Mannheim launches 2nd generation SARS-CoV-2 RT-PCR assay with room temperature storage

, 29 March 2021/in Product News /by panglobal

Erba’s ErbaMDx SARS-CoV-2 RT-PCR Kit for detection of SARS-CoV-2 in now available in countries accepting the CE Mark.

AMSBIO introduces HER2 cell line array for breast cancer research

ProBioGen licenses GlymaxX tech to Sanofi

Bio-Rad launches SARS-CoV-2 variant RT-PCR assays

Porvair Sciences launches kits for rapid extraction of total RNA

Shimadzu’s iMScope QT wins Red Dot Design Award 2021

AMSBIO offers animal-free enzymes for in-vitro tissue dissociation

Porvair Sciences launches new generation Ultravap Levante nitrogen blowdown sample evaporator

Nova blood gas analysers add important new test – estimated plasma volume

Beckman Coulter’s SARS-CoV-2 IgG II antibody test approved in countries accepting CE Mark

ERBA Mannheim launches 2nd generation SARS-CoV-2 RT-PCR assay with room temperature storage

Latest issue of Clinical laboratory

New Chromsystems Product for Antiepileptic Drugs Testing

Trusted analytical solutions for reliable results

Chromsystems | Therapeutic Drug Monitoring by LC-MS/MS

Free subscription

Get our e-alert