SOTIO Biotech, a clinical stage immuno-oncology company owned by PPF Group, has exercised its first of five exclusive, target-specific options with LegoChem Biosciences for antibody-drug conjugate (ADC) SOT106, which is currently being evaluated in preclinical studies across a multitude of solid tumour indications.
In November of 2021, SOTIO and LCB entered into a multi-target exclusive collaboration and license agreement under which SOTIO obtained the rights to deploy LCB’s ADC technology for up to five ADC programmes. SOTIO is responsible for the research, development, manufacturing and worldwide commercialization of the ADC products.
“We are pleased with the progress we have made this year  on our innovative antibody-drug conjugate pipeline. We advanced our lead programme targeting CLDN18.2, SOT102 into the Phase 1 dose escalation portion of the CLAUDIO-01 trial and have now exercised this option for SOT106. ADCs remain one of the most actively pursued drug classes in oncology and we are encouraged that SOT106, an ADC with the potential to treat some of the most challenging solid tumour indications, continues to show promise in preclinical studies,” said Radek Spisek, M.D., Ph.D., chief executive officer of SOTIO. “The rapid and successful development of this collaboration with LegoChem Biosciences reiterates our commitment to providing patients with efficacious and safe cancer therapeutic options.”
The exercise of the first option triggers an undisclosed milestone payment by SOTIO to LCB.
SOT106 is a novel ADC based on SOTIO Biotech’s proprietary antibodies and LCB’s industryleading ConjuAll ADC platform technology with potential best-in class efficacy, safety and tolerability currently in preclinical development against multiple solid tumour indications.