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Author Archive for: 3wmedia
Entries by 3wmedia
Genomic tracking of MRSA outbreaks could help infection control
Hospital-acquired infections (HAIs) today rank among the major causes of death and morbidity in hospitalized patients and are estimated to be responsible for 175,000 deaths per year in industrialized countries. HAIs have been growing exponentially worldwide since the 1980s primarily because of the indiscriminate use of antibiotics which have triggered the growth of multidrug resistant […]
Is a celiac screen in a ‘tired all the time’ test profile of any value?
by L. Hughes, Dr A. Ballantyne, Dr C. Ford, Dr A. Ekbote and Prof. R. Gama Celiac disease (CD) is a common autoimmune gastrointestinal disease. Several serological tests are available to screen for CD. Since CD can present with fatigue, serological screening was incorporated into a ‘tired all the time’ testing profile available to general […]
Evaluation of a highly automated fecal calprotectin assay for the differential diagnosis of IBD or IBS
Fecal calprotectin is an effective biomarker in the differential diagnosis of inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS). Since the National Institute for Health and Care Excellence (NICE) recommended its use there has been a significant increase in demand for analysis. New methods on mainline chemistry analysers can be implemented in response to […]
Calprotectin use in primary care. Are testing criteria being followed?
In 2013, the National Institute for Health and Care Excellence (NICE) published guidelines recommending the use of fecal calprotectin as a screening test for differentiating between inflammatory bowel disease and irritable bowel syndrome. Since then, despite a relatively slow uptake with only a few laboratories offering the test, fecal calprotectin has garnered much interest with […]
Multiplex determination of ANA and cytoplasmic antibodies according to ICAP
by Dr Jacqueline Gosink The international consensus on standardized nomenclature of human epithelial cell (HEp-2 cell) patterns in indirect immunofluorescence (ICAP, www.anapatterns.org) defines fifteen nuclear patterns, nine cytoplasmic patterns and five mitotic patterns which are relevant for the diagnosis of various autoimmune diseases. Furthermore, the consensus stipulates that autoantibodies detected by indirect immunofluorescence on HEp-2 […]
Adrenal cortex antibodies
by Dr Petraki Munujos The detection of anti-adrenal cortex antibodies, also known as 21-hydroxylase or 21-OH antibodies, is an aid in the diagnosis and treatment of autoimmune adrenalitis. Far from being outdated, indirect immunofluorescence is a major analytical procedure used in the autoimmune laboratory for the measurement of these autoantibodies. Several techniques can be currently […]
Chest pain and elevated cardiac troponin: a typical case of myocardial infarction? Perhaps not…
Chest pain is a common presentation in Emergency Medicine and can cause a diagnostic dilemma. Does the patient need urgent admission for percutaneous coronary intervention following a myocardial infarction? Or will discharge with reassurance and a bottle of antacids sort out their indigestion? Measurement of cardiac troponin has become an essential part of emergency assessment […]
MTHFR, hyperhomocysteinemia, CAD and T2DM
Individuals with type 2 diabetes mellitus (T2DM) are at increased risk of coronary artery disease (CAD). The C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene is associated with elevated plasma levels of homocysteine. The association of the MTHFR gene and the level of homocysteine with development of CAD has been studied in various population groups, […]